ArticleNaunyn-Schmiedeberg's archives of pharmacology2026
Evaluation of caffeic acid fenethyl ester in testicular damage caused by fluoxetine hydrochloride in rats: effects of fluoxetine hydrochloride on testes.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
In our study, the aim was to investigate the protective effect of caffeic acid phenethyl ester, which has a wide spectrum of activity, against testicular damage caused by fluoxetine hydrochloride. In our study, 25 male Wistar Albino rats were used, and the rats were divided into five groups with an equal number of rats in each group: control 1 (saline), control 2 (dimethyl sulfoxide-DMSO), fluoxetine group (FLX), caffeic acid phenethyl ester group (CAPE), and fluoxetine + caffeic acid phenethyl ester group (FLX + CAPE). After a 4-week experiment, blood samples were collected, and testicular tissues were excised. For light microscopic evaluation, hematoxylin-eosin (H&E) and toluidine blue (TB) staining were performed. Immunohistochemical examinations were carried out with caspase-3, Bcl-2, and PCNA immunostaining. As a result of statistical evaluation of the morphologic and immunohistochemical examinations, it was determined tubule diameter (p < 0.001, η
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