ReviewCancer metastasis reviews2025
One-carbon metabolism in cancer: moonlighting functions of metabolic enzymes and anti-tumor therapy.
Review in Cancer metastasis reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Review
- Integrated Multi-Omics Analysis of Gut Microbiota-Associated Metabolites and Related Host Molecular Signatures in Cervical Squamous Cell Carcinoma.Applied biochemistry and biotechnology · 2026Article
- RBMX promotes colorectal liver metastasis by stabilizing MTHFD2 mRNA to regulate redox homeostasis.Cellular and molecular life sciences : CMLS · 2026Article
- Genetic Interruption of PD-1/PD-L1 as an Alternative Means for Immune Checkpoint Blockade in Cancer: A Review.Pharmaceutics · 2026Review
- Crosstalk BetweenCancers · 2026Review
- One-carbon metabolism in cancer immunity: T-cell fitness, epigenetic programming, and therapeutic opportunities.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
One-carbon (1C) metabolism is a central metabolic network that supports nucleotide biosynthesis, amino acid metabolism, and redox homeostasis, playing a critical role in cellular proliferation. In cancer, dysregulation of this pathway fuels tumor progression by satisfying the heightened biosynthetic and energetic demands of malignant cells. Beyond their canonical metabolic roles, metabolites and enzymes within the one-carbon metabolic network exhibit moonlighting functions that contribute to tumorigenesis, immune evasion, and metastasis. These non-canonical functions include modulation of gene expression, epigenetic remodeling, and rewiring the oncogenic signaling pathways, underscoring their multifaceted roles in cancer biology. This review explores the production and utilization of one-carbon units, with a focus on the metabolic enzymes involved and their moonlighting functions in tumorigenesis. Additionally, we summarize the progress of ongoing clinical trials targeting the 1C network, highlighting the potential to exploit metabolic vulnerabilities for cancer therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.