ArticlePlant cell reports2025
ERF3 represses SA pathway defense to modulate tradeoffs between biotic and abiotic stress responses in Arabidopsis.
Article in Plant cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- The Regulatory Army of Plant Defense: Transcription Factors in the War for Plant Immunity.International journal of molecular sciences · 2026Review
- Role of phytohormones and nanomaterials in enhancing plant tolerance to abiotic stress.Frontiers in plant science · 2026Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
key messageAs a repressor of SA pathway, ERF3 is induced by pathogens to repress the expression of SA pathway genes and promote JA-mediated wounding and ABA-mediated abiotic-stress responses in defense response. ERF/AP2 family transcription factors play crucial roles in plant growth, development, and stress responses. However, the function of most family members remains unclear. Here, the role of ERF3 in disease resistance was investigated by transcriptomic sequencing. erf3 mutants are more resistant, whereas ERF3-overexpression (ERF3-OE) plants are more susceptible to bacterial pathogen Pst DC3000 than wild type. Through transcriptomic sequencing, we identified 175 differentially expressed genes (DEGs) between erf3 and wild-type plants, including 44 up-regulated (erf3up) and 131 downregulated genes (erf3down) in erf3. GO analysis showed that erf3up DEGs were most significantly enriched in defense response, including SA pathway marker genes PR2 and PR5, and defense genes RLP23, WRKY53, and RAV2 which play positive roles in resistance against Pst DC3000. By contrast, erf3down DEGs were significantly enriched in response to wounding/jasmonic acid, response to abscisic acid/water deprivation, etc., but no components of JA pathway disease resistance were down-regulated by loss of ERF3 function, indicating ERF3 positively regulate JA-mediated wounding and ABA-mediated abiotic-stress responses upon pathogen infection. ERF3 is induced by Pst DC3000, SA and JA, and ERF3 protein was detected to enrich on PR5 and RAV2 which harbor DRE boxes on the promoter and are up-regulated in erf3 mutants. Overall, ERF3 functions as a repressor in SA pathway disease resistance, and upon pathogen infection, ERF3 is induced to repress the expression of SA pathway genes and promote JA-mediated wounding and ABA-mediated abiotic-stress responses. Our work provides novel insights into the potential of exploiting ERF3 function to enhance plant disease resistance.
Indexed as
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41389240What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.