ArticleCell reports2025
Parietal cortex is causally required for state-dependent decisions.
Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Selective filtering of relevant sensory signals in parietal cortex.Research square · 2026Article
Corrections and comments
- Update of
Authors and funding
6 authors.
Funding
Abstract
During perceptual decision-making, behavioral performance varies with internal states like arousal, motivation, and strategy, but how these fluctuations impact distributed neural processes remains unclear. We trained mice on a navigation-based sound-localization task and examined how behavioral performance state changes relate to neural processing in cortex. Hidden Markov modeling shows that expert mice alternate between a high-performance state with optimal stimulus weighting and low-performance states characterized by high choice bias. Optogenetic inactivation of the posterior parietal cortex (PPC) decreases task accuracy and increases occupation of biased performance states. Two-photon calcium imaging shows that performance states strongly influence population activity in the PPC but not the primary auditory cortex. Individual PPC neurons are better explained by external inputs during biased performance, while shared neural variability is strongest during high-performance states. These findings demonstrate that parietal cortex activity is causally required for decisions and is linked to behavioral performance states.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.