Evidence map›Paper›PMID 41389203›Full record

ArticleCell reports2025

Retrograde control of sympathetic neuron-satellite glia interactions by target-derived NGF signaling.

Raniki Kumari, Erica Boehm, Raluca Pascalau, Rebecca L Pfeiffer, Bryan W Jones, Emmanouil Tampakakis, Rejji Kuruvilla

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Raniki KumariDepartment of Biology, Johns Hopkins University, Baltimore, MD 21218, USA.
Erica BoehmDepartment of Biology, Johns Hopkins University, Baltimore, MD 21218, USA.
Raluca PascalauDepartment of Biology, Johns Hopkins University, Baltimore, MD 21218, USA.
Rebecca L PfeifferUPMC Vision Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15219, USA.
Bryan W JonesUPMC Vision Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15219, USA.
Emmanouil TampakakisDivision of Cardiology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Rejji KuruvillaDepartment of Biology, Johns Hopkins University, Baltimore, MD 21218, USA. Electronic address: rkuruvilla@jhu.edu.

Funding

Retinal CircuitryR01EY028927 · NEI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Bryan William Jones · 2019 to 2026
$5.2M
Neuron-satellite glia interactions in the sympathetic nervous systemR01NS133423 · NINDS · JOHNS HOPKINS UNIVERSITY · PI Rejji Kuruvilla · 2023 to 2026
$2.3M
Coupled axonal protein synthesis and lipidation in axon growth and homeostasisR01NS114478 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KURUVILLA, REJJI · 2020 to 2024
$2.2M
Engineering a power switch to study the contribution of stem cell-derived cardiomyocytes on heart regenerationK08HL145135 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI TAMPAKAKIS, EMMANOUIL · 2019 to 2023
$859k
NEI NIH HHS R01 EY028927NHLBI NIH HHS K08 HL145135NINDS NIH HHS R01 NS114478NINDS NIH HHS R01 NS133423
6 · The paper itself

Abstract

Satellite glial cells (SGCs) are the major glial cells in sympathetic ganglia contacting neuronal cell bodies. The intimate association of SGCs with sympathetic neurons ideally positions these glia as critical regulators of neuronal homeostasis, architecture, and function. However, how these neuron-glia interactions are established remains unclear. Here, we find a contact-mediated pathway triggered by retrograde signaling from innervated sympathetic targets that underlies neuron-SGC interactions, neuronal morphology, and functional output. We show that neuronal expression of a transmembrane protein, Delta/Notch-like EGF-related receptor (DNER), is dependent on signaling by target-derived nerve growth factor (NGF). Neuronal DNER deletion disrupts neuron-SGC contacts and results in aberrant neuronal morphology, including decreased soma size and hyper-innervation of targets in mice. DNER mutant neurons have elevated activity, and mice lacking neuronal DNER exhibit increased heart rate and thermogenesis, indicative of enhanced sympathetic tone. These results suggest a mechanism whereby innervated targets control assembly of functional neuron-glia units in the sympathetic nervous system.

Indexed as

Nerve Growth FactorNeurogliaNeuronsSignal TransductionAnimalsCell CommunicationGanglia, SympatheticMiceNerve Growth Factorautonomic functionsCP: cell biologyCP: neurosciencedevelopmentheart rateneuronal activityneuronal morphologyneuron-glia interactionsnon-shivering thermogenesissatellite glial cellssympathetic neuron

Identifiers

PMID41389203
PMCPMC12821072

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.