Evidence map›Paper›PMID 41389179›Full record

ReviewTopics in current chemistry (Cham)2025

Merging Multicomponent Reactions and Metal-Free C-H Functionalization: Emerging Tools in Organic Synthesis.

Ariful Islam, B Shriya Saikia, Pranjal K Baruah

Abstract readReview
PubMed Publisher
In one paragraph

Review in Topics in current chemistry (Cham), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ariful IslamDepartment of Applied Sciences, GUIST, Gauhati University, Guwahati, Assam, 781014, India.
B Shriya SaikiaDepartment of Applied Sciences, GUIST, Gauhati University, Guwahati, Assam, 781014, India.
Pranjal K BaruahDepartment of Applied Sciences, GUIST, Gauhati University, Guwahati, Assam, 781014, India. baruah.pranjal@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pursuit of metal-free multicomponent reactions (MCRs) via direct C-H bond functionalization represents a significant stride toward sustainable and atom-economical organic synthesis. This review comprehensively examines advances from 2016 to 2025 in metal-free C-H functionalization strategies integrated with MCRs for the efficient construction of complex, bioactive heterocycles. Key mechanistic platforms explored include iminium ion activation, azomethine ylide chemistry, radical-mediated transformations, visible-light photoredox catalysis, and base-mediated protocols. Each approach is critically analyzed in terms of substrate scope, regioselectivity and stereoselectivity, green metrics, and practical applicability. The strategic use of renewable feedstocks, solvent-free conditions, and recyclable catalysts further highlights the field's alignment with green chemistry principles. Collectively, these methodologies underscore the growing potential of metal-free MCRs in delivering structurally diverse heterocyclic scaffolds for pharmaceutical and materials applications.

Indexed as

CarbonChemistry Techniques, SyntheticHeterocyclic CompoundsCatalysisGreen Chemistry TechnologyMetalsMolecular StructureCarbonHeterocyclic CompoundsMetalsC–H functionalizationGreen chemistryHeterocyclic chemistryMetal-freeMulticomponent reaction

Identifiers

PMID41389179

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.