ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2026
Correlation between right vagus nerve cross-sectional area and abnormal heart rate with deep breathing in Parkinson's disease.
Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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Who cites it
1 citing paper in PubMed.
- Brain-first versus body-first Parkinson's disease: Differential findings on pupillary, brainstem and vagus sonography.Journal of neurology · 2026Article
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Authors and funding
4 authors.
Funding
Abstract
purposeAutonomic dysfunction, including early cardiovascular parasympathetic involvement, is sustained throughout Parkinson's disease (PD). The vagus nerve, shown by ultrasonography, is atrophic in PD patients. We examined vagus nerve cross-sectional area (CSA) in controls versus PD patients, and its association with autonomic function in early PD.
methodsWe investigated 118 de novo PD patients and 29 controls. Vagus nerve CSA was measured using nerve ultrasonography at the bilateral mid-cervical area. Each patient was evaluated once by a randomly assigned sonographer; each control was measured twice by both. For accurate comparison, patients with diabetes were additionally excluded from the PD group. A 1:1 propensity score matching based on age, sex, hypertension, and dyslipidemia was performed. The CSA was compared between matched patients and controls. Clinical interviews, rating scales, and autonomic and olfactory function tests were performed. The association between these results and the CSA was analyzed.
resultsMedian right and left vagus nerve CSA measured 1.3 and 1.2 mm
conclusionSmall right vagus nerve CSA is associated with early parasympathetic dysfunction in PD patients. These findings support the use of vagus nerve ultrasound as a potential non-invasive biomarker for identifying prodromal autonomic involvement and informing future early intervention research.
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