Evidence map›Paper›PMID 41389094›Full record

ArticleFish physiology and biochemistry2025

Suppression of brain aromatase decreases the expression of dopaminergic neuron in early development of zebrafish.

Ratu Fatimah, Zulvikar Syambani Ulhaq, Muhammad Ahya Rafiuddin, Mitsuyo Kishida

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Article in Fish physiology and biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Ratu FatimahGraduate School of Science and Technology, Kumamoto University, 2-39-1 Kurokami, Kumamoto, 860-8555, Japan.
Zulvikar Syambani UlhaqGraduate School of Science and Technology, Kumamoto University, 2-39-1 Kurokami, Kumamoto, 860-8555, Japan.
Muhammad Ahya RafiuddinGraduate School of Science and Technology, Kumamoto University, 2-39-1 Kurokami, Kumamoto, 860-8555, Japan.
Mitsuyo KishidaGraduate School of Science and Technology, Kumamoto University, 2-39-1 Kurokami, Kumamoto, 860-8555, Japan. mkishida@gpo.kumamoto-u.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytochrome P450 aromatase, the product of the CYP19A1 gene, is a key enzyme in estrogen biosynthesis. Most teleost fish have two distinct isoforms of aromatase, ovarian aromatase (AroA) and brain aromatase (AroB) encoded by cyp19a1a and cyp19a1b, respectively. Although aromatase is expressed in the brain across vertebrates, it is present at uniquely high levels in teleost fish, where its role in brain development is not fully understood. Therefore, in this study, the effects of exposure to fadrozole (Fad), an aromatase inhibitor, and knockdown of the AroB gene by using a morpholino antisense oligonucleotide (MO) on the expression of dopaminergic (DAergic) neurons were investigated in zebrafish embryos and larvae. Fad exposure decreased the expression of tyrosine hydroxylase (TH) as detected by immunostaining at 48 h post fertilization (hpf) and impaired locomotor activities including tactile response at 72 hpf and swimming distance at 6 days post fertilization (dpf), which was reversed by the addition of 17β-estradiol (E

Indexed as

AromataseBrainDopaminergic NeuronsZebrafishAnimalsLocomotionZebrafish ProteinsAromataseCyp19a1a protein, zebrafishZebrafish ProteinsBrain aromataseDopaminergic neuronEarly developmentFadrozoleMorpholinoZebrafish

Identifiers

PMID41389094

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.