ArticleSkin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)2025
Establishing an Improved Cellular Photoaging Model by Repeated UVA Exposure of Human Skin Fibroblasts.
Article in Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Silk Fibroin Peptides Promote Extracellular Matrix Homeostasis in Photoaging via Modulation of the ITGB1/FAK-TGF-β/Smad Signaling Axis.Molecules (Basel, Switzerland) · 2026Article
- Establishing an Improved Cellular Photoaging Model by Repeated UVA Exposure of Human Skin Fibroblasts.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2025Article
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9 authors.
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Abstract
backgroundRepeated ultraviolet A (UVA) exposure-induced cellular photoaging models had been widely applicated to study skin photoaging. However, there is no standard protocol to prepare these models and cell passaging is inevitably needed when fibroblasts are cultured in conventional media for 5-7 days. MATERIALS AND
methodsThe adhesion ability of fibroblasts was tested after UVA irradiation. And both the cell culture medium and the UVA dose were optimized to help fibroblasts surviving a 7-day culture period without cell subculture and to establishing an improved cellular photoaging model. Finally, senescence-associated β-galactosidase staining, intracellular reactive oxygen species (ROS) detection with the fluorescent redox probe dichlorodihydrofluorescein diacetate (DCFH-DA), and Western blot analysis were performed to compare the improved model with the classical model.
resultsUVA exposure induced a significant decrease in the adhesion ability of fibroblasts, and thus implied that cell passaging might be a screen pressure against the photodamaged cells. And fibroblasts incubated in the medium supplemented with 1% fetal calf serum could survive the 7-day culture period without cell subculture and tolerate UVA irradiation up to a dose of 5.8 J/cm
conclusionAn improved cellular photoaging model was established, which seems to be more suitable than the classical model for elucidating the underlying molecular mechanisms of skin photoaging.
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