Evidence map›Paper›PMID 41388927›Full record

SynthesisClinical cardiology2025

GLP-1 and Dual GLP-1/GIP Receptor Agonists in Heart Failure With Mildly Reduced or Preserved Ejection Fraction: A Systematic Review and Meta-Analysis.

Mushood Ahmed, Muhammad Burhan, Aimen Shafiq, Tallal Mushtaq Hashmi, Raheel Ahmed, Marat Fudim, Robert J Mentz, Gregg C Fonarow

Abstract readLetterMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Clinical cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mushood AhmedRawalpindi Medical University, Rawalpindi, Pakistan.ORCID https://orcid.org/0000-0001-9872-8224
Muhammad BurhanRawalpindi Medical University, Rawalpindi, Pakistan.ORCID https://orcid.org/0009-0009-4129-8062
Aimen ShafiqDow University of Health Sciences, Karachi, Pakistan.
Tallal Mushtaq HashmiRawalpindi Medical University, Rawalpindi, Pakistan.ORCID https://orcid.org/0009-0006-6355-3907
Raheel AhmedDepartment of Cardiology, Royal Brompton Hospital, London, UK.ORCID https://orcid.org/0000-0003-2814-7314
Marat FudimDuke University Medical Center, Division of Cardiology, Durham, North Carolina, USA.
Robert J MentzDuke University Medical Center, Division of Cardiology, Durham, North Carolina, USA.
Gregg C FonarowAhmanson-UCLA Cardiomyopathy Center, Division of Cardiology, University of California Los Angeles, Los Angeles, California, USA.ORCID https://orcid.org/0000-0002-3192-8093

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This comprehensive meta-analysis reveals that GLP-1 and dual GLP-1/GIP receptor agonists are associated with reduced risk of composite cardiovascular endpoints and worsening heart failure events. However, no statistically significant differences were observed regarding all-cause or cardiovascular mortality.

Indexed as

Glucagon-Like Peptide 1Glucagon-Like Peptide-1 Receptor AgonistsHeart FailureIncretinsReceptors, Gastrointestinal HormoneStroke VolumeVentricular Function, LeftGlucagon-Like Peptide-1 ReceptorHumansTreatment Outcomegastric inhibitory polypeptide receptorGlucagon-Like Peptide 1Glucagon-Like Peptide-1 ReceptorGlucagon-Like Peptide-1 Receptor AgonistsIncretinsReceptors, Gastrointestinal Hormone

Identifiers

PMID41388927
PMCPMC12701558

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.