Evidence map›Paper›PMID 41388915›Full record

ArticlePharmaceutical biology2026

(±)-Rutacycoumarins A and B: two pairs of unprecedented coumarin enantiomers from the aerial part of

Xu Feng, Jing Fang, Yanyang Liu, Chengyu Ge, Xiaolin Liao, Tao Jiang, Xiongjun Hou, Hao Huang, Shao Liu, Aimin Wang and 1 more

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Article in Pharmaceutical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Xu FengDepartment of Pharmacy, Xiangya Hospital, Central South University, Changsha, China.
Jing FangDepartment of Pharmacy, Xiangya Hospital, Central South University, Changsha, China.
Yanyang LiuDepartment of Pharmacy, Xiangya Hospital, Central South University, Changsha, China.
Chengyu GeDepartment of Pharmacy, Xiangya Hospital, Central South University, Changsha, China.
Xiaolin LiaoDepartment of Clinical Pharmacy, Hunan University of Medicine General Hospital, Huaihua, China.
Tao JiangDepartment of Emergency, Hunan University of Medicine General Hospital, Huaihua, China.
Xiongjun HouDepartment of Pharmacy, Jiangxi Provincial People's Hospital, the First Affiliated Hospital of Nanchang Medical College, Nanchang, China.
Hao HuangJiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, School of Pharmacy, Gannan Medical University, Ganzhou, China.
Shao LiuDepartment of Pharmacy, Xiangya Hospital, Central South University, Changsha, China.
Aimin WangNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
Yueping JiangDepartment of Pharmacy, Xiangya Hospital, Central South University, Changsha, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextBenzofuran derivatives are important structural motifs found in natural products, often exhibiting significant biological activities.

objectiveThis study aimed to isolate and characterize compounds from the aerial parts of MATERIALS AND

methodsThe structures of benzofuran enantiomers were elucidated using integrated NMR, HRMS, and ECD analyses. (±)-Rutacycoumarins A and B were synthesized

resultsTwo novel Z/E pairs of benzofuran enantiomers, (±)-Rutacycoumarins A and B, featuring fused cyclopropane motifs, were isolated and structurally confirmed. Their synthesis employed a novel catalytic EDA complex (DIPEA/potassium ethyl xanthate donor, NHPI ester acceptor). (±)-Rutacycoumarins A and B reduced liver biomarkers and pro-inflammatory cytokines in LPS-treated HepG2 cells, and all four enantiomers inhibited MAO-B.

conclusionsThis study isolated two novel benzofuran enantiomer pairs with fused cyclopropane motifs from

Indexed as

Anti-Inflammatory AgentsCoumarinsMonoamine Oxidase InhibitorsPlant ExtractsRutaHep G2 CellsHumansPlant Components, AerialStereoisomerismAnti-Inflammatory AgentsCoumarinsMonoamine Oxidase InhibitorsPlant Extractsantihepatitic activitycoumarin enantiomersmonoamine oxidase B inhibitory activityRuta graveolens L.

Identifiers

PMID41388915
PMCPMC12704139

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