ArticleJournal of cosmetic dermatology2025
A Natural Composite Extract Restores Skin Barrier Function by Modulating Inflammatory, Hydration, and Redox Pathways.
Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- A Natural Composite Extract Restores Skin Barrier Function by Modulating Inflammatory, Hydration, and Redox Pathways.Journal of cosmetic dermatology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
objectiveThis study was to evaluate the effects of a composite extract of Prunus mume flower, Lonicera japonica flower (honeysuckle), Chrysanthemum indicum flower, and Phyllostachys bambusoides, which we named PLCP, on skin hydration, inflammation, itching, and oxidative stress in pediatric (NHEK) and adult (HaCaT) keratinocytes.
methodsLPS was used to simulate the external stimulation for pediatric (NHEK) and adult (HaCaT) keratinocytes. These keratinocytes were treated with different concentrations of PLCP, and the expression of inflammation, itching, and oxidative stress-related proteins or mRNA was observed through rt-PCR, ELISA, ROS, and SOD. Meanwhile, rt-PCR was also used to determine the expression of Hyaluronic acid synthase (HAS) in keratinocytes under PLCP intervention for its moisturizing effects.
resultsPLCP treatment (0.125%-0.500%) significantly suppressed LPS-stimulated thymic stromal lymphopoietin (TSLP) secretion by up to 40.3% in pediatric cells and 29.9% in adult cells (p < 0.05), and reduced endothelin-1 (ET-1) mRNA levels by up to 69.5% and 46.0%, respectively (p < 0.05). Concurrently, PLCP dose-dependently upregulated hyaluronic acid synthase isoforms (HAS-1, HAS-2, HAS-3) mRNA expression by 174.8%-254.2% in pediatric keratinocytes and 143.5%-198.9% in adult cells (p < 0.05), indicating enhanced hydration potential. Antioxidant assays demonstrated that PLCP at 0.250% decreased reactive oxygen species (ROS) by 55.3% in pediatric and 41.6% in adult cells, while boosting superoxide dismutase (SOD) activity (p < 0.05).
conclusionsAcross all endpoints, pediatric keratinocytes exhibited more pronounced responses, suggesting age-dependent differences in sensitivity. These in vitro findings support PLCP's multifunctional role at anti-inflammatory, anti-pruritic, moisturizing, and antioxidant and highlight its promise as a safe, plant-based alternative for managing pediatric skin disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.