Evidence map›Paper›PMID 41388841›Full record

ArticleJournal of cosmetic dermatology2025

A Scoping Review of Clinical Trials on the Efficacy of Curcumin and Its Formulations for Wound Healing.

Mohammad Mahdi Parvizi, Ali Arefkia, Yasamin Dehghan, Mohammad Ali Salimi, Negin Fazelzadeh Haghighi

Abstract readScoping Review
In one paragraph

Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mohammad Mahdi ParviziMolecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID https://orcid.org/0000-0003-1856-945X
Ali ArefkiaStudent Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Yasamin DehghanMolecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Mohammad Ali SalimiDepartment of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Negin Fazelzadeh HaghighiMolecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID https://orcid.org/0000-0002-0829-4950

Funding

Shiraz University of Medical Sciences 32392
6 · The paper itself

Abstract

backgroundCurcumin, the main component of turmeric, may be effective in wound healing due to its anti-inflammatory and antibacterial effects. Although pre-clinical studies are promising, a comprehensive clinical review is lacking. This scoping review examines clinical trials on the efficacy of curcumin in wound healing.

methodThis study was conducted in accordance with the PRISMA-ScR guidelines and involved a comprehensive search of PubMed, Scopus, Web of Science, and Cochrane Library databases for clinical trials on various forms of curcumin for wound healing in humans, from January 1, 2000 to May 31, 2025.

resultsA total of 920 results were retrieved through the search, of which 19 clinical trials met the predefined inclusion and exclusion criteria and were included in our study. Most studies (14 out of 19) were randomized controlled trials. Curcumin was used in various dosages and treatment durations, and in multiple forms, including topical and oral formulations. Curcumin improved wound healing compared to placebo or conventional care in 89% of the studies. Additionally, no adverse events were reported in 84% of the studies, with minor and temporary side effects observed in the remaining cases.

conclusionsAccording to the findings of the current study, curcumin is a safe and effective adjuvant for improving wound healing. However, the significant heterogeneity observed among clinical trials limits the ability to develop consistent treatment guidelines. Future studies should focus on large-scale, standardized trials to better define the role of curcumin in wound care.

Indexed as

CurcuminWound HealingAdministration, OralHumansRandomized Controlled Trials as TopicTreatment OutcomeCurcumincomplementary therapiescurcuminPersian medicineplant extractswound healing

Identifiers

PMID41388841
PMCPMC12701545

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.