ArticleJournal of cosmetic dermatology2025
Effect of Dextran-Aminated Hyaluronic Acid Hydrogel on the Repair of Different Degrees of Epidermal Injury.
Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Development, Stability, and Clinical Efficacy of an Oil-in-Serum Formulation with Olive Extract Standardized in Hydroxytyrosol for Post-Inflammatory Hyperpigmentation Treatment.AAPS PharmSciTech · 2026Article
- Effect of Dextran-Aminated Hyaluronic Acid Hydrogel on the Repair of Different Degrees of Epidermal Injury.Journal of cosmetic dermatology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundPostskin peeling procedures commonly result in epidermal injuries with the potential for infection and suboptimal aesthetic outcomes. In clinical practice, dextran and hyaluronic acid (HA) are frequently used as adjunctive materials to enhance wound healing.
aimsTo evaluate the efficacy of a dextran-aminated hyaluronic acid (DA-AHA) hydrogel in epidermal injury repair.
methodsMurine models of stratum corneum and epidermal layer injury were established. Nine mice with disrupted stratum corneum barriers and 45 with disrupted epidermal barriers were randomized into three groups: Saline, HA gel, and DA-AHA. The repair efficacy of the DA-AHA gel was assessed by measuring the trans epidermal water loss (TEWL) at the injury site and conducting skin tissue pathological examinations.
resultsDA-AHA gel more rapidly reduced TEWL at the injury site compared with both saline and HA gel, leading to accelerated wound repair. Pathological and fluorescence staining analyses indicated that DA-AHA gel could form a dense film at the wound site, subsequently reducing inflammatory cell infiltration and tumor necrosis factor-α expression while increasing transforming growth factor-β1 levels. Consequently keratinocyte proliferation, migration, and differentiation were enhanced. Additionally, DA-AHA gel induced the thickening of the epidermal layer during the later stages of repair.
conclusionsDA-AHA gel can expedite the repair of injured epidermis, alleviate inflammation of the affected area, and thicken the epidermal layer. Therefore, DA-AHA gel is an efficacious treatment in epidermal injury repair, with potential clinical application.
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