Evidence map›Paper›PMID 41388753›Full record

ArticleThe FEBS journal2026

Functional divergence of protein kinase A regulatory subunit Iβ variants: the importance of N3A motifs in PKA regulation.

Maximilian Wallbott, Jui-Hung Weng, Valeria Pane, Yuliang Ma, Jian Wu, Susan S Taylor, Friedrich W Herberg

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In one paragraph

Article in The FEBS journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Maximilian WallbottDepartment of Biochemistry, Institute for Biology, University of Kassel, Germany.ORCID 0000-0002-7946-2579
Jui-Hung WengDepartment of Pharmacology, University of California, CA, USA.ORCID 0000-0002-0432-3515
Valeria PaneDepartment of Biochemistry, Institute for Biology, University of Kassel, Germany.ORCID 0009-0005-2283-0819
Yuliang MaDepartment of Biochemistry and Molecular Biophysics, University of California, CA, USA.
Jian WuDepartment of Pharmacology, University of California, CA, USA.ORCID 0000-0002-8031-9462
Susan S TaylorDepartment of Pharmacology, University of California, CA, USA.ORCID 0000-0002-7702-6108
Friedrich W HerbergDepartment of Biochemistry, Institute for Biology, University of Kassel, Germany.ORCID 0000-0001-7117-7653

Funding

Lessons Learned from PKA: Assembly of Dynamic Macromolecular SwitchesR35GM130389 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUSAN S. TAYLOR · 2019 to 2026
$5.7M
Deutsche Forschungsgemeinschaft He1818/-12NIGMS NIH HHS R35 GM130389NIH HHS GM130389Research Training Group GRK 2749 448909517
6 · The paper itself

Abstract

Protein kinase A (PKA) regulatory subunit Iβ (RIβ) plays a crucial role in modulating PKA activity through its interaction with the catalytic (C) subunit. Recent studies have identified two variants of RIβ that have not been distinguished until now. The variants differ in a single residue at Position 268 (alanine vs arginine), located within one of two structural motifs known as N3A motifs. Our study reveals distinct biochemical functions of the variants, highlighting the role of the second N3A motif at the N terminus of the cyclic nucleotide binding domain B (CNB-B). We demonstrate an enhanced binding affinity of the A268 variant for cAMP and an altered interaction with the C-subunit. Substitution in the N3A

Indexed as

Cyclic AMP-Dependent Protein Kinase RIIbeta SubunitCyclic AMP-Dependent Protein KinasesAmino Acid MotifsBinding SitesCatalytic DomainCyclic AMPHEK293 CellsHumansMolecular Dynamics SimulationProtein BindingCyclic AMPCyclic AMP-Dependent Protein Kinase RIIbeta SubunitCyclic AMP-Dependent Protein Kinasesbioluminescence resonance energy transfer (BRET)cAMP signalingmolecular dynamicsprotein kinaseprotein kinase A (PKA)regulatory subunit Iβ (RIβ)Surface plasmon resonance spectroscopy

Identifiers

PMID41388753
PMCPMC13080237

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.