ArticleAngewandte Chemie (International ed. in English)2026
Near-Infrared Triggered Anion Transport Induces Cancer Cell Death.
Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Multi-wavelength photo-activation of transmembrane chloride transport in distinct vesicle populations using photocaged indolocarbazole anionophores.Chemical science · 2026Article
- Near-Infrared Triggered Anion Transport Induces Cancer Cell Death.Angewandte Chemie (International ed. in English) · 2026Article
- Synthesis of Novel Anion Recognition Molecules as Quinazoline Precursors.International journal of molecular sciences · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Artificial transmembrane anion carriers have shown potential in biological research and medicine, such as chemotherapeutics to treat channelopathies and anticancer agents. Stimuli-responsive systems, controlled by triggers such as light, pH, redox, enzymes, or membrane potential, offer the potential for targeted activation. Photoactivation of ion transport is particularly advantageous due to the possibility of achieving spatiotemporal control, remote addressability, and reduced cytotoxicity. However, poor tissue penetration and undesired cytotoxicity are significant drawbacks to many photo-activated ionophores reported to date, which are mostly triggered by UV or violet light. Here, we report BODIPY-caged photo-responsive anionophores activated with NIR light, which utilize dynamic hydrogen bonding interactions of a 4-hydroxyisophthalamide motif. Caging of the hydroxyl group of the anionophore with BODIPY-photocages locks the amide proton through six-membered intramolecular hydrogen bonding, rendering it unavailable for anion recognition and transport. Decaging with 730 nm NIR irradiation reverses the hydrogen bonding pattern to switch on binding, with efficient off-on activation profiles observed in anion transport experiments in vesicles. Analogous experiments in cancer cells revealed turn-on transmembrane chloride transport and a dramatic, dose-dependent decrease in cell viability following NIR decaging of the anionophore, demonstrating the potential for NIR-triggered ionophores as an alternative to existing photodynamic therapies for cancer.
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Registered trials
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