Evidence map›Paper›PMID 41388561›Full record

ArticleAngewandte Chemie (International ed. in English)2026

Enriching Higher Affinity Aptamers by Addressing the Kinetic Aspect of the DNA Strand-Displacement Reaction.

Yuzhe Ding, Yicheng Heng, Ka-Ying Wong, Qingyu Chen, Juewen Liu

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yuzhe DingDepartment of Chemistry, Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada.
Yicheng HengDepartment of Chemistry, Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada.
Ka-Ying WongDepartment of Chemistry, Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada.
Qingyu ChenDepartment of Chemistry, Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada.
Juewen LiuDepartment of Chemistry, Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada.ORCID 0000-0001-5918-9336

Funding

Canada Research Chairs ProgramGovernments of Canada and Ontario under the Sustainable Canadian Agricultural Partnership (Sustainable CAP)Mitacs AccelerateNatural Sciences and Engineering Research Council of Canada (NSERC)
6 · The paper itself

Abstract

Selection of high affinity aptamers is the basis for aptamer-related applications. Most aptamer selections prioritize thermodynamic factors such as the target concentration but neglect interaction kinetics. Using ampicillin as a target, aptamer selections were carried out based on the DNA strand-displacement reaction. A low-affinity aptamer (K

Indexed as

Aptamers, NucleotideDNAAmpicillinKineticsSELEX Aptamer TechniqueThermodynamicsAmpicillinAptamers, NucleotideDNAAmpicillinBiosensorsKineticsSELEXStrand‐displacement

Identifiers

PMID41388561
PMCPMC12850998

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.