Evidence map›Paper›PMID 41388553›Full record

ArticleTrials2025

Abdominal ultrasound (FAST) in hemodynamically stable children with blunt abdominal trauma: study protocol for a randomized controlled trial.

James F Holmes, Daniel J Tancredi, Kenneth M Kelley, Mark Griffiths, Delia L Gold, Samuel H F Lam, Bethsabee Stone, Timothy Brenkert, Amia N Andrade, Eric Hanson and 5 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05910567 (A Randomized Controlled Trial of Abdominal Ultrasound), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05910567 narecruitingnot on this map

A Randomized Controlled Trial of Abdominal Ultrasound (FAST) in Children With Blunt Torso Trauma

TypeinterventionalSponsorUniversity of California, DavisRan2023 to 2027Enrolled4,650ConditionsBlunt Trauma to Abdomen, Wounds and Injuries, Abdomen Injury, Abdominal InjuryArmsFocused Assessment with Sonography for Trauma (FAST) Examination, No Intervention: Standard of Care - Without the FAST Examination
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

James F HolmesDepartment of Emergency Medicine, University of California, Davis School of Medicine, Sacramento, CA, USA. jfholmes@ucdavis.edu.ORCID http://orcid.org/0000-0003-3270-2720
Daniel J TancrediDepartment of Emergency Medicine and Pediatrics, University of California, Davis School of Medicine, Sacramento, CA, USA.
Kenneth M KelleyDepartment of Emergency Medicine, University of California, Davis School of Medicine, Sacramento, CA, USA.
Mark GriffithsDivision of Pediatric Emergency Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Delia L GoldPediatric Emergency Department, School of Medicine, Nationwide Children's Hospital, The Ohio State University, Columbus, OH, USA.
Samuel H F LamDepartment of Pediatrics, Section of Emergency Medicine, School of Medicine, Children's Hospital Colorado, University of Colorado, Denver, CO, USA.
Bethsabee StoneChildren's Medical Center of Dallas, UT Southwestern School of Medicine, Dallas, TX, USA.
Timothy BrenkertDivision of Emergency Medicine, Cincinnati Children's Hospital Medical Center, School of Medicine, University of Cincinnati, Cincinnati, OH, USA.
Amia N AndradeDepartment of Emergency Medicine, University of California, Davis School of Medicine, Sacramento, CA, USA.
Eric HansonDepartment of Emergency Medicine, University of California, Davis School of Medicine, Sacramento, CA, USA.
Kriti GwalDepartment of Radiology, Nemours Children's Hospital, Orlando, FL, USA.
Aaron KornblithDepartment of Emergency Medicine and Pediatrics, University of California San Francisco School of Medicine, San Francisco, CA, USA.
Shinjiro HiroseDepartment of Surgery, University of California, Davis School of Medicine, Sacramento, CA, USA.
Garth H UtterDepartment of Surgery, University of California, Davis School of Medicine, Sacramento, CA, USA.
Nathan KuppermannDepartments of Pediatrics and Emergency Medicine, School of Medicine and Health Sciences, George Washington University, Washington, D.C., USA.

Funding

Accurate and Reliable Diagnostics for Injured Children: Machine Learning for UltrasoundK23HD110716 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Aaron Edward Kornblith · 2023 to 2026
$650k
NICHD NIH HHS K23 HD110716
6 · The paper itself

Abstract

backgroundHemorrhage from intra-abdominal injuries (IAI) is a leading cause of traumatic deaths in children. Concern over misdiagnosing IAIs has resulted in excessive use of abdominal computed tomography (CT). Despite its many benefits, CT presents risks to children most notably radiation-induced malignancies. Thus, we must safely limit abdominal CT evaluation to those at non-negligible risk. The focused assessment with sonography for trauma (FAST) examination uses abdominal ultrasonography to detect the presence of intraperitoneal fluid in injured patients and may decrease abdominal CT use in some children. Limited and conflicting data exists on the utility of the FAST examination in children. A large multicenter study is thus necessary to determine if the FAST examination should routinely be included in the diagnostic evaluation of injured children.

methodsThis is a multicenter, randomized controlled clinical trial to assess the impact of the FAST examination on the initial evaluation of children with blunt abdominal trauma. Enrolled participants will be randomized 1:1 to the FAST examination plus routine care or routine care alone during their initial emergency department (ED) evaluation. The study will enroll 3194 (initial sample size) to 4346 (second sample size) children at six diverse sites. The primary outcomes are as follows: (1) The proportion of abdominal CT in the initial 24 h of care and (2) the proportion of missed or delayed diagnoses of IAIs. Secondary outcomes include (1) ED length of stay, (2) hospitalization proportion and length of hospital stay, (3) physician suspicion of IAI, (4) the proportion of abdominal CT use in the subgroup of children 0 to 3 years old, and (5) laparotomy proportion. Hospitalized participants will be followed through their stay, and guardians of those discharged from the ED will be contacted after 1 week to assess their status. DISCUSSION: The study will determine if the FAST examination results in a safe reduction of CT use in injured children and will provide definitive evidence if the FAST examination should be routinely implemented in the initial evaluation of children with blunt abdominal trauma.

trial registrationClinicalTrials.gov NCT05910567. Registered on May 9, 2023.

Indexed as

Abdominal InjuriesFocused Assessment with Sonography for TraumaHemodynamicsWounds, NonpenetratingAdolescentAge FactorsChildChild, PreschoolEmergency Service, HospitalFemaleHumansInfantMaleMulticenter Studies as TopicPredictive Value of TestsRandomized Controlled Trials as Topic

Identifiers

PMID41388553
PMCPMC12699813

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.