Evidence map›Paper›PMID 41388478›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

OPTRACE: Optical Imaging-Guided Transplantation and Tracking of Cells in the Mouse Brain.

Jinghui Wang, Honglin Tan, Colleen Russell, Mikolaj Walczak, Dawei Gao, Guanda Qiao, Xiaoxuan Fan, Chengyan Chu, Miroslaw Janowski, Piotr Walczak and 1 more

Abstract read
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In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Jinghui WangDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Honglin TanDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Colleen RussellDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Mikolaj WalczakDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Dawei GaoDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Guanda QiaoDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Xiaoxuan FanDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Chengyan ChuDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Miroslaw JanowskiDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Piotr WalczakDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Yajie LiangDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.ORCID https://orcid.org/0000-0002-4798-4882

Funding

Shedding light on functional heterogeneity of dementia-related alpha-synuclein strainsR21AG077631 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI LIANG, YAJIE · 2022 to 2022
$463k
Altered pH in early Alzheimer's disease detected by creatine chemical exchange saturation transfer MRIR21AG074978 · NIA · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI XU, JIADI · 2022 to 2022
$444k
Intravital 2-photon microscopy enabling 6D single cell RNA seq in immunocompetent glioblastoma xenograftsR03NS123733 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI LIANG, YAJIE · 2021 to 2022
$155k
Intravital 2-photon imaging the integration of transplanted embryonic neurons in a mouse model of cerebral ischemia at the subacute phaseR03NS128459 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI LIANG, YAJIE · 2022 to 2023
$155k
Maryland Department of Health's Cigarette Restitution Fund Program CH-649-CRFMaryland Stem Cell Research Fund 2022-MSCRFD-5886Maryland Stem Cell Research Fund 2022-MSCRFL-5893Maryland Stem Cell Research Fund for the postdoc fellowship 2024-MSCRFF-6328National Cancer Institute-Cancer Center Support Grant (CCSG) P30CA134274NIA NIH HHS R21 AG077631NIH HHS R03NS123733NIH HHS R03NS128459NIH HHS R21AG074978NIH HHS R21AG077631NINDS NIH HHS R03 NS128459
6 · The paper itself

Abstract

Intracerebral cell transplantation holds promise for treating stroke and neurological disorders, yet challenges in precise delivery and post-engraftment monitoring impede progress. This work introduces OPTRACE (OPtical imaging-guided Transplantation and tRAcking of CElls), a two-step optical framework integrating real-time visualization during transplantation with longitudinal post-transplantation in vivo cell tracking. Leveraging cost-effective translucent glass micropipettes and two innovative predictive mathematical modeling-the retention-depth model (predicts retained fraction versus injection depth) and the hypoperfusion-volume model (predicts hypoperfused fraction versus graft volume)-that this work fits to data (depth-retention R

Indexed as

BrainCell TrackingCell TransplantationOptical ImagingAnimalsMiceMice, Inbred C57BLimage‐guided transplantationmodeling cell injectionstem cell therapystroketwo‐photon fluorescence microscopy

Identifiers

PMID41388478
PMCPMC12948288

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.