ArticleJournal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG2026
The role of phototherapy in reducing the risk of psoriatic arthritis among psoriasis patients in the era of biologics.
Article in Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND AND
objectivesBiologic therapies for psoriasis have shown promise in reducing the risk of Psoriatic Arthritis (PsA) by targeting inflammatory pathways. Emerging evidence suggests that phototherapy may also exert systemic anti-inflammatory effects. This study examines the impact of phototherapy on the progression to PsA. PATIENTS AND
methodsThis exploratory, hypothesis generating retrospective cohort study comprised 667 psoriatic patients, subclassified based on therapeutic interventions administered during longitudinal follow-up: phototherapy alone; phototherapy combined with systemic therapy [either conventional agents (e.g., methotrexate, acitretin, cyclosporine) or biologics (e.g., TNF inhibitors, anti-IL-12/23, anti-IL-17A, anti-IL-23A); topical therapy alone; and systemic monotherapy. PsA diagnoses were established in accordance with the Classification Criteria for Psoriatic Arthritis.
resultsPatients receiving standalone phototherapy exhibited a reduced PsA incidence compared to those on topical agents (4.09 vs 5.30 events per 100 person-years; HR = 0.73; 95 % CI: 0.53-0.99; p = 0.047). Combining phototherapy with systemic therapy further reduced PsA risk compared to systemic monotherapy (2.26 vs 3.74 events per 100 person-years; HR = 0.56; 95 % CI: 0.38-0.82; p = 0.003). The lowest incidence was observed in patients treated with both phototherapy and biologics, outperforming biologics alone (HR = 0.43; 95 % CI: 0.19-0.93; p = 0.03).
conclusionsPhototherapy, especially in combination with systemic treatments, demonstrates synergistic potential in mitigating PsA risk.
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