Evidence map›Paper›PMID 41388473›Full record

ArticleBMC research notes2025

Association between Helicobacter pylori infection and the types of tumor markers among Yemeni gastric cancer patients: a case-control study.

Gamil Taher Abdulmughni, Afeef Said Al-Nabhi, Amal Adnan Al-Sheibani, Naif Mohammed Al-Haidary, Arwa Mohammed Othman, Kamal Hamoud Jahzar, Asma'a Ahmed Al-Hnhna

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Article in BMC research notes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Gamil Taher AbdulmughniDepartment of Microbiology and Immunology, Faculty of Laboratory Medicine, University of 21 September for Medical and Applied Sciences, Sana'a, Yemen.
Afeef Said Al-NabhiDepartment of Internal Medicine, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a, Yemen.
Amal Adnan Al-SheibaniDepartment of Medical Microbiology and Immunology, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a, Yemen.
Naif Mohammed Al-HaidaryDepartment of Medical Microbiology and Immunology, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a, Yemen.ORCID https://orcid.org/0009-0004-4389-1285
Arwa Mohammed OthmanDepartment of Medical Microbiology and Immunology, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a, Yemen. arwaothman@hotmail.com.ORCID https://orcid.org/0000-0001-5893-2247
Kamal Hamoud JahzarBiomedical Science Department, Lebanese International University, Sana'a Campus, Sana'a, Yemen.
Asma'a Ahmed Al-HnhnaGastroenterology and Hepatology, Medicine Department, 21 September University, Sana'a, Yemen.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study aims to investigate the relationship between H. pylori infection and types of tumor markers (CEA and CA19-9) among Yemeni gastric cancer patients, comparing the frequency of these markers in patients with and without H. pylori infection.

resultsSerum CEA and CA19-9 levels were measured among 85 patients with H. pylori infection (cases) and 85 without (controls). The median CEA levels were 7.05 ng/mL in H. pylori positive group and 7.14 ng/mL in negative group. The median CA19-9 levels were 33 U/mL in H. pylori positive group and 32 U/mL in negative group. No significant differences were found in the serum levels of CEA (p = 0.44) or CA19-9 (p = 0.94) between the two groups. However, a significant association was observed between H. pylori infection and gastric cancer site in cardia and fundus regions (p = 0.047). This study found no significant association between H. pylori infection and types of tumor markers (CEA and CA19-9) among Yemeni gastric cancer patients. However, the significant association between H. pylori infection and site of gastric cancer in cardia and fundus regions needs further investigations to reveal the associated mechanisms.

Indexed as

Biomarkers, TumorCA-19-9 AntigenCarcinoembryonic AntigenHelicobacter InfectionsHelicobacter pyloriStomach NeoplasmsAdultAgedCase-Control StudiesFemaleHumansMaleMiddle AgedYemenBiomarkers, TumorCA-19-9 AntigenCarcinoembryonic AntigenGastric cancerHelicobacter pyloriTumor markersYemen

Identifiers

PMID41388473
PMCPMC12817680

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