ArticleBMC surgery2025
The correlation between the systemic immune-inflammatory index and the risk of major adverse cardiovascular events after transcatheter aortic valve replacement: a retrospective cohort study.
Article in BMC surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Systemic Inflammatory Burden Is Independently Associated with Anemia After Transcatheter Aortic Valve Implantation in Patients Referred to Cardiac Rehabilitation.Biomedicines · 2026Article
- A novel composite inflammatory-metabolic index for long-term prognosis after TAVR: the modifying role of left ventricular ejection fraction.Frontiers in cardiovascular medicine · 2026Article
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Authors and funding
10 authors.
Funding
Abstract
aimsThis study aimed to explore the association between the systemic immune-inflammatory index (SII) and major adverse cardiovascular events (MACE) after transcatheter aortic valve replacement (TAVR).
methodsThis retrospective cohort study included 138 patients who underwent TAVR surgery. SII was defined as an exposure variable, and MACE, including the occurrence of one or more of the following: all-cause death, cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke, was defined as an outcome variable. Univariate and multivariate Cox regression analyses, subgroup analyses, receiver operating characteristic curve (ROC) and restricted cubic spline plot (RCS) were used to explore the association between SII and MACE.
resultsDuring the median follow-up period of 12.5 months, 22 patients experienced MACE (15.94%). Compared with those without MACE, patients in the MACE group had higher levels of SII (P < 0.05). In multivariate Cox regression analysis, after adjusting for potential confounders, higher levels of SII were still statistically associated with a higher hazard of MACE. Each 1-standard deviation increase in SII was associated with a 29.7% higher hazard of MACE (hazard ratio [HR] = 1.297, 95% confidence interval [CI]: 1.054-1.597, P = 0.014). The subgroup analyses based on the Model 3 indicated that SII remained associated with MACE in most subgroups (P < 0.05). The ROC curve analysis indicated that SII showed a modest discriminatory ability for MACE (AUC = 0.697, 95% CI: 0.578-0.815, P = 0.004). The RCS analysis indicated a positive linear association between SII and MACE (P-nonlinear > 0.05).
conclusionIn patients undergoing TAVR, a higher level of SII was associated with a higher risk of MACE. However, these findings still require further validation in larger, multicenter prospective clinical trials.
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