Evidence map›Paper›PMID 41388430›Full record

ArticleClinical epigenetics2025

Noninvasive early diagnosis of laryngeal squamous cell carcinoma (LSCC) revealing the high-performance potential of the HOXD10 gene monomethylated locus: a case-control study.

Xiaoyang Gong, Zhaoyi Lu, Zihang Zhu, Qin Zhang, Haibing Chen, Han Zhou, Qianqian Duan, Chan Zhu, Dongsheng Chen, Lei Cheng and 2 more

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Article in Clinical epigenetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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12 authors.

Xiaoyang Gong *Department of Otorhinolaryngology, The First Affiliated Hospital with Nanjing Medical University, No. 300 Guangzhou Road, Nanjing, 210029, China.
Zhaoyi Lu *Department of Otorhinolaryngology, The First Affiliated Hospital with Nanjing Medical University, No. 300 Guangzhou Road, Nanjing, 210029, China.
Zihang Zhu *Department of Otorhinolaryngology, The First Affiliated Hospital with Nanjing Medical University, No. 300 Guangzhou Road, Nanjing, 210029, China.
Qin Zhang *The State Key Laboratory of Neurology and Oncology Drug Development, Jiangsu Simcere Diagnostics Co., Ltd, Nanjing, 210042, China.
Haibing ChenDepartment of Otorhinolaryngology, The First Affiliated Hospital with Nanjing Medical University, No. 300 Guangzhou Road, Nanjing, 210029, China.
Han ZhouDepartment of Otorhinolaryngology, The First Affiliated Hospital with Nanjing Medical University, No. 300 Guangzhou Road, Nanjing, 210029, China.
Qianqian DuanThe State Key Laboratory of Neurology and Oncology Drug Development, Jiangsu Simcere Diagnostics Co., Ltd, Nanjing, 210042, China.
Chan ZhuThe State Key Laboratory of Neurology and Oncology Drug Development, Jiangsu Simcere Diagnostics Co., Ltd, Nanjing, 210042, China.
Dongsheng ChenThe State Key Laboratory of Neurology and Oncology Drug Development, Jiangsu Simcere Diagnostics Co., Ltd, Nanjing, 210042, China.
Lei ChengDepartment of Otorhinolaryngology, The First Affiliated Hospital with Nanjing Medical University, No. 300 Guangzhou Road, Nanjing, 210029, China.
Xin CaoDepartment of Medical Genetics, School of Basic Medical Science, Nanjing Medical University, No.101 Longmian Avenue, Nanjing, 211166, China. caoxin@njmu.edu.cn.
Xi ChenDepartment of Otorhinolaryngology, The First Affiliated Hospital with Nanjing Medical University, No. 300 Guangzhou Road, Nanjing, 210029, China. chenxi2882@jsph.org.cn.

Funding

2023 Clinical Capacity Enhancement Project Medical Project of Jiangsu Provincial People's Hospital JSPH-MA-2023-1Natural Science Foundation of Jiangsu Province BK20230739
6 · The paper itself

Abstract

Laryngeal squamous cell carcinomas (LSCCs) was a frequent malignancy in upper aerodigestive tract. The lack of non-invasive biomarkers for early diagnosis has led to unfavorable prognosis. We firstly identified methylation biomarkers from TCGA and GEO databases. We further validated the diagnostic performance by utilizing blood samples obtained from 43 LSCCs and 50 normal controls (NCs). The HOXD10 cg10364040 was hypermethylated in tumors compared with NCs (P < 0.01), with an area under the curve (AUC) greater than 0.90 in each public database. In clinical validation phase, HOXD10 cg10364040 methylation was able to discriminate LSCCs from NCs with high accuracy (AUC = 0.767, sensitivity: 72.1%, specificity: 82.0%), and exhibited greater sensitivity (85.0%) and specificity (86.0%) in stage I patients than in NCs (AUC = 0.864). In summary, we firstly identified cg10364040 as a novel diagnosis biomarker of LSCC and confirmed it as a noninvasive biomarker in clinical.

Indexed as

Carcinoma, Squamous CellDNA MethylationEarly Detection of CancerHomeodomain ProteinsLaryngeal NeoplasmsSquamous Cell Carcinoma of Head and NeckTranscription FactorsAdultAgedBiomarkers, TumorCase-Control StudiesFemaleHumansMaleMiddle AgedSensitivity and SpecificityBiomarkers, TumorHomeodomain ProteinsHOXD10 protein, humanTranscription FactorsDNA methylationEarly diagnosisHOXD10Laryngeal squamous cell carcinomaNoninvasive diagnostic marker

Identifiers

PMID41388430
PMCPMC12817775

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