Mercury-induced neurotoxicity in rat: in vivo and in silico studies of thymoquinone modulatory effect via oxidative stress and inflammation, HO-1/NRF/Trx/Trx-R trajectories.

Solomon Owumi, Moses Otunla, Jesutosin O Babalola, Uche Arunsi, Chioma E Irozuru, Ahmad Altayyar, Olatunde Owoeye

Abstract read

In one paragraph

Article in BMC veterinary research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Journal of experimental pharmacology · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Solomon OwumiDepartment of Biochemistry, Cancer Research and Molecular Biology Laboratory, University of Ibadan, Ibadan, 200005, Oyo State, Nigeria. zicri@hotmail.com.ORCID http://orcid.org/0000-0002-4973-0376

Moses OtunlaDepartment of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, , Lexington, KY, 40536-0298, USA.

Jesutosin O BabalolaDepartment of Biochemistry, Nutritional and Industrial Chemistry Research Laboratories, University of Ibadan, Ibadan, 200005, Oyo State, Nigeria.

Uche ArunsiDepartment of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, 30332-0400, USA.

Chioma E IrozuruDepartment of Chemistry and Biochemistry, Montana State University, Bozeman, MT, 59719, USA.

Ahmad AltayyarUniversity of Nottingham, Nottingham, NG7 2RD, UK.

Olatunde OwoeyeDepartment of Anatomy, Neuroanatomy Research Laboratories, University of Ibadan, Ibadan, 200005, Oyo State, Nigeria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mercury exposure has been associated with the onset of neurodegenerative disorders via mechanisms that include oxidative stress, inflammation, and apoptosis. Thymoquinone (TQ) has been documented to possess antioxidant, anti-inflammatory, and apoptotic modulatory effects. We assessed TQ's neuroprotective potential against mercuric chloride (HgCl

Indexed as

BenzoquinonesMercuric ChlorideNeuroprotective AgentsOxidative StressAnimalsAntioxidantsApoptosisInflammationLipid PeroxidationMaleRatsRats, WistarAntioxidantsBenzoquinonesMercuric ChlorideNeuroprotective AgentsthymoquinoneAnti-inflammatoryAntioxidantApoptosisMercuric chlorideNeurobehaviouralThymoquinone

Identifiers

PMID41388407

DOI10.1186/s12917-025-05093-0

PMCPMC12811909

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Textmetadata

LicenceCC BY-NC-ND

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.