Evidence map›Paper›PMID 41388376›Full record

ArticleBMC infectious diseases2025

Uncovering metabolic shifts: an ¹H-NMR study on the dual influence of HIV/TB coinfection and ART.

Steven Patrick Ahumada Prado, Shayne Mason, Robin Wood, Laneke Luies

Abstract read
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In one paragraph

Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Steven Patrick Ahumada PradoBiomedical and Molecular Metabolism Research Group, North-West University, Potchefstroom Campus, Private Bag X6001, Box 269, Potchefstroom, North West, 2520, South Africa.ORCID http://orcid.org/0000-0002-1925-9069
Shayne MasonBiomedical and Molecular Metabolism Research Group, North-West University, Potchefstroom Campus, Private Bag X6001, Box 269, Potchefstroom, North West, 2520, South Africa.ORCID http://orcid.org/0000-0002-2945-5768
Robin WoodDesmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.ORCID http://orcid.org/0000-0002-4276-7117
Laneke LuiesBiomedical and Molecular Metabolism Research Group, North-West University, Potchefstroom Campus, Private Bag X6001, Box 269, Potchefstroom, North West, 2520, South Africa. laneke.luies@nwu.ac.za.ORCID http://orcid.org/0000-0003-4920-4090

Funding

Identifying TB transmitters in high TB/HIV burdened communitiesR01AI147347 · NIAID · DESMOND TUTU HIV FOUNDATION · PI WOOD, ROBIN · 2019 to 2023
$4.0M
National Institute of Allergy and Infectious Diseases R01AI147347National Research Foundation 129871NIAID NIH HHS R01 AI147347South African Medical Research Council MRC-RFA-UFSP-01-2013/CCAMP
6 · The paper itself

Abstract

backgroundHuman immunodeficiency virus (HIV) and tuberculosis (TB) coinfection pose a substantial global health burden, with each infection amplifying the immune and metabolic impacts of the other. Investigating the compounded metabolic disruptions in HIV/TB coinfection and how these are modulated by antiretroviral therapy (ART) offers information into disease mechanisms and therapeutic strategies.

methodsThis study used untargeted proton nuclear magnetic resonance metabolomics to characterize the urine samples from three participant groups: healthy controls, treatment-naive HIV/TB coinfected individuals, and ART-treated HIV/TB coinfected individuals.

resultsSignificant metabolite shifts were observed across gut microbiota, energy, amino acid, and carbohydrate metabolism. Metabolomic profiles of HIV/TB coinfection suggested mitochondrial perturbation, markers of insulin resistance, and microbial dysbiosis. ART was associated with partial restoration of mitochondrial function, stabilization of gut microbiota, and reduced oxidative stress. However, glucose dysregulation appeared to persist. Key metabolites, including phenylacetylglycine and trans-aconitic acid, emerged as potential differential markers for coinfection and treatment response.

conclusionART modulates metabolic pathways disrupted by HIV/TB coinfection, showing partial improvements but leaving glucose metabolism dysregulated. These findings highlight the potential of targeted metabolic monitoring to optimize coinfection treatment strategies. Further investigations are needed in larger cohorts to validate these results and better understand coinfection pathophysiology.

Indexed as

Anti-Retroviral AgentsCoinfectionHIV InfectionsTuberculosisAdultFemaleGastrointestinal MicrobiomeHumansMaleMetabolomeMetabolomicsMiddle AgedProton Magnetic Resonance SpectroscopyAnti-Retroviral Agents¹H-NMR metabolomicsAntiretroviral therapy (ART)Gut microbiotaHIV/TB coinfectionHuman immunodeficiency virus (HIV)Metabolic biomarkersMitochondrial stressTuberculosis (TB)

Identifiers

PMID41388376
PMCPMC12817673

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.