ArticleAdvanced materials (Deerfield Beach, Fla.)2026
Unfolding and Degradation of Micellar Immunodrug Carriers Derived From End Group Modified Aliphatic Poly(Carbonate)s with Acid-Responsive Ketal Side Groups.
Article in Advanced materials (Deerfield Beach, Fla.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Aliphatic Poly(Carbonate)s with Acid Responsive Release Mechanisms for Micellar Anti-Tumor Drug Delivery.Macromolecular rapid communications · 2026Review
- Unfolding and Degradation of Micellar Immunodrug Carriers Derived From End Group Modified Aliphatic Poly(Carbonate)s with Acid-Responsive Ketal Side Groups.Advanced materials (Deerfield Beach, Fla.) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
Abstract
Small-molecule immunodrugs hold significant promise for immunotherapeutic applications including vaccination and cancer therapy. However, their clinical use is limited by severe side effects resulting from systemic distribution. To address this challenge, a biodegradable, acid-responsive nanocarrier system designed for controlled immunodrug delivery in vivo is presented. It is based on polymeric micelles that disassemble in response to acidic environments, enabling site-specific particle unfolding following endocytosis by antigen-presenting cells. Its core structure features a hydrolysable aliphatic poly(carbonate) backbone, promoting both biocompatibility and biodegradability. The high precision of the applied ring-opening polymerization allows for polymer end group functionalization, including the integration of fluorophores for Förster resonance energy transfer (FRET)-based monitoring of particle integrity and unfolding. The observations reveal a pH-dependent disassembly profile both in vitro and in vivo. Comparative studies with non-responsive poly(carbonate)s demonstrate the superior performance of the acid-responsive design in selectively disassembling under acidic conditions and enhancing polymer backbone degradation. Furthermore, covalent conjugation of a small molecule Toll-like receptor 7/8 agonist promotes its controlled delivery in vitro and in vivo, resulting in improved immune cell uptake and regulated cytokine production. The findings underscore the potential of this biodegradable, acid-responsive micellar nanocarrier system as precision delivery platform for safer and effective immunotherapeutics.
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Registered trials
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