Evidence map›Paper›PMID 41388297›Full record

ArticleCancer cell international2025

CD9-positive tumor-associated macrophages promote renal cell carcinoma progression by activating the orphan nuclear receptor Nor1/Nr4a3.

Pengyu Pan, Shiyuan Li, Wanru Yin, Peng Wang, Tongtong Ma, Ziqian Bi, Junhao Song, Xinyuan Song, Xin Huang, Junfeng Hao and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer cell international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Pengyu Pan *Department of Integrated Traditional Chinese and Western Medicine, Xinglin College of Liaoning University of Traditional Chinese Medicine, Liaoning, Shenyang, 110135, China.
Shiyuan Li *Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, 116011, China.
Wanru Yin *Department of Dermatovenereology, Shenyang Medical College, Shenyang, 110034, China.
Peng WangDepartment of Nephrology, National Clinical Key Specialty Construction Program (2023), Institute of Nephrology, Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-communicable Diseases; Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Tongtong MaDepartment of Anesthesiology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524000, Guangdong, China.
Ziqian BiFaculty of Information Technology, Beijing University of Technology, Beijing, 100083, China.
Junhao SongChina Agricultural University, 17 Tsinghua East Road, Beijing, 100083, China.
Xinyuan SongSchool of Physics, Peking University, Beijing, 100871, China.
Xin HuangDepartment of Family Medicine, Shengjing Hospital of China Medical University, Shenyang, 110022, China.
Junfeng HaoDepartment of Nephrology, National Clinical Key Specialty Construction Program (2023), Institute of Nephrology, Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-communicable Diseases; Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China. junfenghao2022@163.com.
Guangqi ChenDepartment of Urology, The First Hospital of China Medical University, Shenyang, China, 110000. wzhoucmu@163.com.
Qiuyu ZhaoDepartment of Integrated Traditional Chinese and Western Medicine, Xinglin College of Liaoning University of Traditional Chinese Medicine, Liaoning, Shenyang, 110135, China. zhaoqiuyulutcm@163.com3.com.

Funding

The high-level talents scientific research start-up funds of the Affiliated Hospital of Guangdong Medical University (1007Z20220002)Zhanjiang Science and Technology Plan Project (2022A01160)
6 · The paper itself

Abstract

Tumor growth, metastasis, and treatment response in renal cell carcinoma (RCC) are believed to be regulated by the tumor microenvironment (TME). However, the mechanisms underlying the genomic, transcriptomic, and epigenetic alterations in clear cell RCC progression remain incompletely understood. This study analyzed single-cell RNA sequencing data from public databases, including tissue samples from three patients with RCC and three matched pairs of immune cells from tumor tissue and peripheral blood to screen macrophages with differential expression in the TME. We found that a CD9

Indexed as

CD9Renal cell carcinomaTumor-associated macrophagesTumor microenvironment

Identifiers

PMID41388297
PMCPMC12817849

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.