Evidence map›Paper›PMID 41388289›Full record

ArticleJournal of nanobiotechnology2025

Targeting pre-metastatic niche with inhalable dendritic cell vesicles to prevent breast cancer lung metastasis.

Qingqing Leng, Zhengxin Yu, Yu Zhao, Yue Shao, Qiuyang Jin, Qiyu Zhao, Ying Yang, Mengmeng Ji, Hua Yang, Lili Ren and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Qingqing LengCollege of Pharmaceutical Science, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding, 071002, China.
Zhengxin YuCollege of Pharmaceutical Science, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding, 071002, China.
Yu ZhaoCollege of Pharmaceutical Science, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding, 071002, China.
Yue ShaoCollege of Pharmaceutical Science, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding, 071002, China.
Qiuyang JinCollege of Pharmaceutical Science, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding, 071002, China.
Qiyu ZhaoCollege of Pharmaceutical Science, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding, 071002, China.
Ying YangCollege of Chemistry & Materials Science, Chemical Biology Key Laboratory of Hebei Province, Hebei University, Baoding, 071002, China.
Mengmeng JiCollege of Chemistry & Materials Science, Chemical Biology Key Laboratory of Hebei Province, Hebei University, Baoding, 071002, China.
Hua YangAffiliated Hospital of Hebei University, Baoding, 071000, China.
Lili RenAffiliated Hospital of Hebei University, Baoding, 071000, China.
Guang JiaCollege of Chemistry & Materials Science, Chemical Biology Key Laboratory of Hebei Province, Hebei University, Baoding, 071002, China.
Xueyi WangThe Tenth Affiliated Hospital, Southern Medical University (Dongguan People's Hospital), Dongguan, 523059, China.
Jinchao ZhangCollege of Chemistry & Materials Science, Chemical Biology Key Laboratory of Hebei Province, Hebei University, Baoding, 071002, China. zjc@hbu.edu.cn.
Zhenhua LiThe Tenth Affiliated Hospital, Southern Medical University (Dongguan People's Hospital), Dongguan, 523059, China. zhenhuali@hbu.edu.cn.
Huifang LiuCollege of Pharmaceutical Science, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding, 071002, China. liuhuifang@hbu.edu.cn.

Funding

National Natural Science Foundations of China 32471460
6 · The paper itself

Abstract

Distant metastasis remains the primary cause of mortality in breast cancer, yet therapeutic options to prevent or treat metastatic progression are still limited. Emerging evidence suggests that the formation of the pre-metastatic niche (PMN) serves as a pivotal step in the process of breast cancer metastasis. Lung tissue is the major site of breast cancer metastasis with elevated prostaglandin E2 (PGE

Indexed as

Breast NeoplasmsDendritic CellsLung NeoplasmsAnimalsCell Line, TumorDinoprostoneFemaleHumansMiceMice, Inbred BALB CDinoprostoneDendritic cell dysfunctionDendritic extracellular vesicleLung metastasisPre-metastatic nicheProstaglandin E2 antagonists

Identifiers

PMID41388289
PMCPMC12699861

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.