Trial reportBMC anesthesiology2025
Efficacy of opioid-free anesthesia in reducing postoperative adverse events for thoracoscopic pulmonary surgery: a randomized controlled trial.
Trial report in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04507165 (The Effect of Opioid-free Anesthesia on Postoperative Analgesia-related Adverse Reactions in Lung Resection With Video-assisted Thoracoscopic Access), which is not on this map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Opioid-free Anesthesia on Postoperative Analgesia-related Adverse Reactions in Lung Resection With Video-assisted Thoracoscopic Access: a Randomized Double-blind Controlled Study
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study compared the effects of opiate-free anesthesia (OFA) using thoracic paravertebral block combined with dexmedetomidine versus traditional anesthesia with sufentanil and remifentanil on postoperative adverse reactions after thoracoscopic lung surgery.
methodsA prospective, randomized, double-blind trial included 97 patients(49 in OFA group,48 in S group).All received preoperative thoracic paravertebral block.The primary outcome was the incidence of opioid-related adverse reactions (hypoxemia, hypotension, nausea, vomiting, dizziness) at 2,4,6,24,and 48 h postoperatively.Secondary outcomes included intraoperative events, pain scores, opioid consumption, time to first flatus/defecation, and cardiovascular complications.
resultsAt 2 h postoperatively, hypotension incidence was lower in the OFA group(8.2%vs 33.3%,P = 0.002),with fewer overall adverse reactions (18.4%vs 39.6%,P = 0.018).At 24 h, PONV was 0%in OFA vs. 10.4%in S group(P = 0.027),dizziness was 8.2%vs 22.9%(P = 0.041),and overall adverse reactions were 10.2%vs 27.1%(P = 0.029).OFA had fewer vasopressor applications (P < 0.001), lower 24-hour opioid use (P = 0.033), fewer analgesic pump presses(P = 0.004),and earlier first feeding (9.5 ± 3.8 h vs. 11.4 ± 4.7 h, P = 0.035).
conclusionOFA significantly reduced opioid-related adverse reactions, decreased vasopressor and opioid use, and improved recovery.However, the single-center, small-sample design limits generalizability, and multicenter validation is needed.
trial registrationThis randomized controlled trial was registered on clinicaltrials.gov (ID: NCT04507165; URL: https://clinicaltrials.gov/study/NCT04507165 , 11/08/2020).
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