ArticleBMC neuroscience2025
Sex-specific cypermethrin-induced hippocampal neurotoxicity is associated with alterations in signaling molecules for antioxidant defense, membrane integrity, apoptosis, and GABAergic integrity.
Article in BMC neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Callosal glia, GABAergic interneurons, and apoptotic profiles in the brains of cypermethrin-exposed male and female rats.BMC research notes · 2026Article
- Valproate-vitamin E co-treatment preserved cortico-callosal white matter integrities in cypermethrin co-exposed pentylene tetrazole induced seizure.BMC neuroscience · 2025Article
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Authors and funding
11 authors.
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Abstract
Cypermethrin(CP), a widely used pesticide, is recognized for its neurotoxic potential. The hippocampus is particularly susceptible to such damage, and sex may influence susceptibility. We investigated sex-specific hippocampal neurotoxicity following short-term CP exposure in rats, focusing on oxidative stress, apoptosis, membrane integrity, and GABAergic interneuron function. Adult male and female Wistar rats (n = 8/group/sex) were orally exposed to corn oil (vehicle control), low (6.25 mg/kg), or high (12.5 mg/kg) doses of CP for 14 days. High-dose CP induced significant weight loss in both males (p = 0.0055) and females (p = 0.0025). CP caused dose-dependent and sex-dependent alterations: females showed greater vulnerability in Na⁺/K⁺-ATPase and COX-2 suppression (treatment × sex interaction, p < 0.05), while males exhibited reduced Nrf2 expression, indicating impaired antioxidant response. Apoptotic markers revealed a distinct pattern; females showed robust Caspase-3 activation alongside increased BCL-2, whereas males displayed a net reduction in BCL-2. Furthermore, CP disrupted parvalbumin-positive GABAergic interneurons, with males showing greater susceptibility to this effect. Collectively, these findings demonstrate that CP induces sex-dependent hippocampal neurotoxicity, with males more vulnerable to oxidative stress and neuronal loss, and females to apoptotic signaling and GABAergic disruption. Understanding such sex-specific vulnerabilities is crucial for risk assessment.
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