Evidence map›Paper›PMID 41388201›Full record

ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2026

Primary focal hyperhidrosis and autonomic symptom burden: a case-control study using the COMPASS-31 questionnaire.

Andrei Gurau, Wasay Nizam, Hamza Khan, Nimisha Seshadri, Christine Kim, Suguru Yamauchi, Rita de Cássia Collaço, Ruilin Ma, Kaitlyn Ecoff, Jolien Vander Cruyssen and 6 more

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Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. A neurocutaneous NaScience advances · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Andrei GurauDivision of Thoracic Surgery, Department of Surgery, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Blalock 240, Baltimore, MD, 21287, USA.ORCID http://orcid.org/0000-0003-4610-721X
Wasay NizamDepartment of Surgery, Howard University College of Medicine, 2041 Georgia Ave NW, Room 4B-16, Washington, DC, 20060, USA.
Hamza KhanDivision of Thoracic Surgery, Department of Surgery, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Blalock 240, Baltimore, MD, 21287, USA.
Nimisha SeshadriDepartment of Psychology, University of California Los Angeles, 502 Portola Plaza, Los Angeles, CA, 90095, USA.
Christine KimDepartment of Biology, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD, 21218, USA.
Suguru YamauchiDivision of Thoracic Surgery, Department of Surgery, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Blalock 240, Baltimore, MD, 21287, USA.
Rita de Cássia CollaçoMolecular Physiology and Neurophysics Group, Department of Basic and Applied Medical Sciences, Faculty of Medicine and Public Health, University of Ghent, 9000, Ghent, Belgium.
Ruilin MaDepartment of Biology, New York University, New York, NY, 10003, USA.
Kaitlyn EcoffDivision of Thoracic Surgery, Department of Surgery, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Blalock 240, Baltimore, MD, 21287, USA.
Jolien Vander CruyssenMolecular Physiology and Neurophysics Group, Department of Basic and Applied Medical Sciences, Faculty of Medicine and Public Health, University of Ghent, 9000, Ghent, Belgium.
Jeannine ForresterDivision of Thoracic Surgery, Department of Surgery, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Blalock 240, Baltimore, MD, 21287, USA.
Kristen RodgersDivision of Thoracic Surgery, Department of Surgery, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Blalock 240, Baltimore, MD, 21287, USA.
Andreas S BarthDepartment of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD, 21287, USA.
Frank BosmansMolecular Physiology and Neurophysics Group, Department of Basic and Applied Medical Sciences, Faculty of Medicine and Public Health, University of Ghent, 9000, Ghent, Belgium.
Jinny S HaDivision of Thoracic Surgery, Department of Surgery, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Blalock 240, Baltimore, MD, 21287, USA.
Malcolm BrockDivision of Thoracic Surgery, Department of Surgery, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Blalock 240, Baltimore, MD, 21287, USA. mabrock@jhmi.edu.ORCID http://orcid.org/0000-0003-2961-851X

Funding

Clinical and Laboratory Research Training for Surgical OncologistsT32CA126607 · NCI · JOHNS HOPKINS UNIVERSITY · PI CAMERON, ANDREW M. · 2008 to 2024
$6.0M
Sodium channel mutations as a possible cause for primary dysautonomiaR01NS126398 · NINDS · JOHNS HOPKINS UNIVERSITY · PI MALCOLM V BROCK · 2023 to 2026
$1.9M
American Heart Association 23CSA1053305NCI NIH HHS T32CA126607NIH HHS R01NS126398
6 · The paper itself

Abstract

purposeTo explore the relationship between primary focal hyperhidrosis (PFH) and generalized autonomic dysfunction, we assessed autonomic symptom burden using a comprehensive and validated measure of autonomic symptoms.

methodsIn this case-control study, we compared 132 patients with PFH with 74 matched healthy controls. Autonomic symptoms were assessed using the Composite Autonomic Symptom Score-31 (COMPASS-31) questionnaire. Propensity score matching minimized confounding. Mann-Whitney U tests compared COMPASS-31 scores between groups. A sensitivity analysis using multivariate linear regression accounted for specific hyperhidrosis sites and demographic factors.

resultsPFH cases demonstrated significantly higher median COMPASS-31 scores compared to controls (18.7 [IQR 7.7-34.8] vs. 11.2 [IQR 3.5-19.3], p < 0.001). Significant differences were observed in orthostatic (2.0 [0-20] vs. 0 [0-12], p = 0.028), vasomotor (0 [0-0] vs. 0 [0-0], p = 0.005; 24.2% vs. 9.5% non-zero scores, respectively), secretomotor (3.2 [2.1-8.6] vs. 0 [0-3.8], p < 0.001), and gastrointestinal (5.4 [1.8-8] vs. 1.8 [0.9-5.4], p = 0.004) domains. Sensitivity analysis confirmed PFH status as a significant predictor of higher COMPASS-31 scores (additional 7.5 points on average, 95% CI 1.6-13.4, p = 0.012) after adjusting for demographic factors and hyperhidrosis sites. Craniofacial and truncal hyperhidrosis were associated with higher autonomic symptom burden.

conclusionPFH is associated with a broader spectrum of autonomic symptoms beyond localized sweating, establishing a link to more generalized autonomic dysfunction. These findings underscore the need for a comprehensive approach to evaluating and managing patients with PFH.

Indexed as

Autonomic Nervous System DiseasesHyperhidrosisAdultCase-Control StudiesFemaleHumansMaleMiddle AgedSurveys and QuestionnairesSymptom BurdenYoung AdultAutonomic dysfunctionCase–control studyCOMPASS-31DysautonomiaPrimary focal hyperhidrosisSympathetic nervous system

Identifiers

PMID41388201

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.