ArticleChemistry (Weinheim an der Bergstrasse, Germany)2026
Highly Efficient Organocatalytic House-Meinwald Rearrangement for the Facile Synthesis of Aldehydes: Swift Access to Ibuprofen.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Unlocking Lewis acid-free metalation of O-nucleophiles in HFIP.Communications chemistry · 2026Article
- Highly Efficient Organocatalytic House-Meinwald Rearrangement for the Facile Synthesis of Aldehydes: Swift Access to Ibuprofen.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
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Authors and funding
4 authors.
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Abstract
We present a new organocatalytic method for synthesizing aldehydes under mild conditions using readily accessible terminal epoxides as starting materials and bis(trifluoromethane)sulfonimide (Tf2NH) as the catalyst. We identified intermediate aldehyde dimerization products at lower temperatures and observed their cleavage at 55°C. We isolated the products in yields of 89-97% using catalyst loadings as low as 0.5 mol%. To underline the applicability of our new approach, we synthesized ibuprofen in a three-step process and overall yield of 90%.
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