Evidence map›Paper›PMID 41388161›Full record

ArticleCell biology and toxicology2025

SIRT3-SUMO regulated Treg cell differentiation and asthma development by mediating N-glycosylation through the FAO pathway.

Yan Hu, Chuntao Liu

Abstract read
In one paragraph

Article in Cell biology and toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Yan HuDepartment of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, 37 Guoxue Lane, Wuhou District, Chengdu City, 610000, Sichuan Province, China.
Chuntao LiuDepartment of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, 37 Guoxue Lane, Wuhou District, Chengdu City, 610000, Sichuan Province, China. taosen666999@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Asthma, a chronic inflammatory disease, has a high disability rate, which greatly increases the disease burden. T cells are pivotal in the pathogenesis of asthma, and Treg cells, due to their role in maintaining immune system balance, represent a promising avenue for therapeutic intervention. Initial weighted correlation network analysis (WGCNA) analysis of asthma-related datasets indicates that N-glycosylation plays a critical role in asthma development. The establishment of an OVA-sensitized asthma model, along with the isolation of naive CD4

Indexed as

AsthmaCell DifferentiationSirtuin 3T-Lymphocytes, RegulatoryAnimalsDisease Models, AnimalFemaleGlycosylationHumansMiceMice, Inbred BALB COxidation-ReductionSirt3 protein, mouseSirtuin 3AsthmaFatty acid oxidationN- glycosylationSIRT3-SUMOTreg

Identifiers

PMID41388161
PMCPMC12700947

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.