Evidence map›Paper›PMID 41388145›Full record

ArticleMolecular psychiatry2026

Lifestyle shapes preclinical social and microglial deficits in an Alzheimer's disease mouse model.

Fanny Ehret, Birte Doludda, Hang Liu, Sindi Nexhipi, Hao Huang, Fabian Rost, Rupert W Overall, Warsha Barde, Annette E Rünker, Michael Sieweke and 3 more

Abstract read
In one paragraph

Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Fanny EhretInstitute of Anatomy, TU Dresden, 01307, Dresden, Germany. fanny.ehret@tu-dresden.de.ORCID http://orcid.org/0000-0003-4820-0979
Birte DoluddaDZNE - German Center for Neurodegenerative Diseases, 01307, Dresden, Germany.ORCID http://orcid.org/0009-0001-7363-857X
Hang LiuDZNE - German Center for Neurodegenerative Diseases, 01307, Dresden, Germany.
Sindi NexhipiOncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TU Dresden, 01307, Dresden, Germany.ORCID http://orcid.org/0000-0001-9886-4517
Hao HuangCRTD - Center for Regenerative Therapies, TU Dresden, 01307, Dresden, Germany.ORCID http://orcid.org/0000-0003-3878-3947
Fabian RostCRTD - Center for Regenerative Therapies, TU Dresden, 01307, Dresden, Germany.
Rupert W OverallDZNE - German Center for Neurodegenerative Diseases, 01307, Dresden, Germany.
Warsha BardeDZNE - German Center for Neurodegenerative Diseases, 01307, Dresden, Germany.ORCID http://orcid.org/0000-0002-2774-040X
Annette E RünkerDZNE - German Center for Neurodegenerative Diseases, 01307, Dresden, Germany.ORCID http://orcid.org/0000-0002-2524-1041
Michael SiewekeCRTD - Center for Regenerative Therapies, TU Dresden, 01307, Dresden, Germany.
Andreas DahlCRTD - Center for Regenerative Therapies, TU Dresden, 01307, Dresden, Germany.
Mirko H H SchmidtInstitute of Anatomy, TU Dresden, 01307, Dresden, Germany.ORCID http://orcid.org/0000-0001-7411-8835
Gerd KempermannDZNE - German Center for Neurodegenerative Diseases, 01307, Dresden, Germany. gerd.kempermann@dzne.de.ORCID http://orcid.org/0000-0002-5304-4061

Funding

Alzheimer Forschung Initiative (Alzheimer Forschung Initiative e.V.) 19038Volkswagen Foundation (VolkswagenStiftung) 98 597
6 · The paper itself

Abstract

Alzheimer's disease has a long preclinical phase, during which no overt signs of the manifest disease are present, but subtle, usually non-specific changes are already detectable. Emerging early biomarkers underscore the importance of this phase for preventive measures including lifestyle interventions. As a reductionistic model for lifestyle factors, we used a novel enrichment paradigm in which App

Indexed as

Alzheimer DiseaseMicrogliaAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAnimalsBehavior, AnimalBrainDisease Models, AnimalFemaleHippocampusLife StyleMaleMiceMice, Inbred C57BLMice, TransgenicNeurogenesisAmyloid beta-PeptidesAmyloid beta-Protein Precursor

Identifiers

PMID41388145
PMCPMC13099370

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.