Evidence map›Paper›PMID 41388104›Full record

ArticleSurgical endoscopy2026

A novel enhanced two-tooth clip for reliable defect closure endoscopically: An ex vivo comparative and in vivo feasibility study.

Shuqian Hu, Jindong Chu, Yiyu Qiao, Wei Shen, Airong Tang, Hanqing Zhang, Xueting Zhang, Min Min, Yan Liu

Registry-linked trialAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in Surgical endoscopy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07581977 (Efficacy and Safety of a Novel Two-Tooth Clip-Assisted ESD and EFTR of GIST), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07581977 narecruitingnot on this map

Efficacy and Safety of a Novel Two-Tooth Clip-Assisted ESD and EFTR of GIST: A Single-Center, Prospective, Open-Label, Randomized Controlled Study

TypeinterventionalSponsorAffiliated Hospital to Academy of Military Medical SciencesRan2026 to 2027Enrolled60ConditionsGIST - Gastrointestinal Stromal TumorArmsA Novel Two-Tooth Endoscopic Clip, Clip
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shuqian Hu *The School of Medicine, Nankai University, Tianjin, 300071, China.
Jindong Chu *Senior Department of Hepatology, The Fifth Medical Center of PLA General Hospital, Beijing, 100039, China.
Yiyu Qiao *Senior Department of Gastroenterology, The First Medical Center of PLA General Hospital, Beijing, 100071, China.
Wei ShenSenior Department of Gastroenterology, The First Medical Center of PLA General Hospital, Beijing, 100071, China.
Airong TangSenior Department of Gastroenterology, The First Medical Center of PLA General Hospital, Beijing, 100071, China.
Hanqing ZhangSenior Department of Gastroenterology, The First Medical Center of PLA General Hospital, Beijing, 100071, China.
Xueting ZhangSenior Department of Gastroenterology, The First Medical Center of PLA General Hospital, Beijing, 100071, China.
Min MinSenior Department of Gastroenterology, The First Medical Center of PLA General Hospital, Beijing, 100071, China.
Yan LiuSenior Department of Gastroenterology, The First Medical Center of PLA General Hospital, Beijing, 100071, China. 13911798288@163.com.ORCID 0000-0001-5034-8601

Funding

National Natural Science Foundation of China No. 82170677
6 · The paper itself

Abstract

backgroundSecure closure after advanced endoscopic resection remains challenging, especially for large or full-thickness gastrointestinal (GI) defects. We developed a novel two-tooth clip (TTC) with enhanced anchoring capacity and evaluated its mechanical properties, tissue attachment, and clinical feasibility.

methodsThe TTC features inward-facing teeth for improved grip. Its performance was compared with conventional clips through tensile testing and finite element simulation. In vivo clip retention and histologic response were assessed in porcine models. Feasibility was further evaluated in pigs and clinical cases requiring mucosal defect closure.

resultsThe TTC exhibited significantly greater pulling force than conventional clips (4.64 ± 0.11 N vs. 2.05 ± 0.09 N; P < 0.05) and showed more distributed force transmission on simulation. In animal studies, TTCs demonstrated higher retention and good tissue compatibility. In clinical cases, technical and clinical success were achieved in 9 of 10 patients (90.0%), with complete closure of defects up to 6 × 3 cm and no delayed perforation.

conclusionsThe TTC system is safe, effective, and compatible with standard endoscopic workflows. Its dual-tooth design offers enhanced closure strength and stability. Further comparative studies are needed to confirm its clinical value.

Indexed as

Surgical InstrumentsWound Closure TechniquesAgedAnimalsEquipment DesignFeasibility StudiesFemaleHumansMaleMiddle AgedSwineTensile StrengthClinical feasibilityClip anchoring strengthEndoscopic defect closureEndoscopic full-thickness resection (EFTR)Two-tooth clip (TTC)

Identifiers

PMID41388104

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.