Evidence map›Paper›PMID 41388091›Full record

ArticleDiabetologia2026

Superiority of 1 h plasma glucose vs fasting plasma glucose, 2 h plasma glucose and HbA

Yiying Wang, Jagannathan Ram, Cristina Bianchi, Teresa Vanessa Fiorentino, Sang Soo Kim, Jinmi Kim, Soree Ryang, Stefano Del Prato, Giorgio Sesti, Leontine Sandforth and 7 more

Abstract read
In one paragraph

Article in Diabetologia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Yiying WangInstitute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany.ORCID http://orcid.org/0000-0002-1252-7788
Jagannathan RamEmory Global Diabetes Research Center, Woodruff Health Sciences Center and Emory University, Atlanta, GA, USA.
Cristina BianchiDepartment of Endocrine-Metabolic and Transplant Surgery and Medicine, University Hospital of Pisa, Pisa, Italy.
Teresa Vanessa FiorentinoDepartment of Medical and Surgical Sciences, University "Magna Graecia" of Catanzaro, Catanzaro, Italy.ORCID http://orcid.org/0000-0001-9485-8793
Sang Soo KimDivision of Endocrinology and Metabolism, Department of Internal Medicine, Pusan National University Hospital, Busan, Korea.ORCID http://orcid.org/0000-0002-9687-8357
Jinmi KimBiomedical Research Institute, Pusan National University Hospital, Busan, Korea.
Soree RyangDivision of Endocrinology and Metabolism, Department of Internal Medicine, Pusan National University Hospital, Busan, Korea.
Stefano Del PratoInterdisciplinary Research Center "Health Science," Sant'Anna School of Advanced Studies, Pisa, Italy.
Giorgio SestiDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Leontine SandforthInstitute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany.
Hubert PreisslInstitute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany.
Reiner Jumpertz von SchwartzenbergInstitute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany.
Norbert StefanInstitute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany.ORCID http://orcid.org/0000-0002-2186-9595
Andreas FritscheInstitute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany.
Joon HaDepartment of Mathematics, Howard University, Washington, DC, USA.ORCID http://orcid.org/0000-0003-4173-2534
Andreas L BirkenfeldInstitute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany. andreas.birkenfeld@med.uni-tuebingen.de.ORCID http://orcid.org/0000-0003-1407-9023
Michael BergmanNYU Grossman School of Medicine, Department of Medicine and of Population Health, Holman Division of Endocrinology and Metabolism, NYU Langone Diabetes Prevention Program, New York, NY, USA. Michael.Bergman@nyulangone.org.ORCID http://orcid.org/0000-0003-2589-2976

Funding

the German Center for Diabetes Research grant 01GI0925
6 · The paper itself

Abstract

aims/hypothesisThe IDF has proposed 1 h plasma glucose (1 h PG) as a diagnostic test for type 2 diabetes. This study evaluated the utility of 1 h PG in diagnosing type 2 diabetes, compared with fasting plasma glucose (FPG), 2 h plasma glucose (2 h PG), HbA

methodsAnalyses were conducted using data from five independent cohorts: KoGES, CATAMERI, GENFIEV, PLIS (follow-up) and TULIP (follow-up). Type 2 diabetes was defined according to ADA criteria (FPG ≥7.0 mmol/l [≥126 mg/dl], 2 h PG ≥11.1 mmol/l [≥200 mg/dl] or HbA

resultsCohort-specific analyses demonstrated consistently higher AUCs for 1 h PG in KoGES (AUC 0.96 vs 0.88; Δ 0.08; sensitivity 84.2 vs 77.0; specificity 98.6 vs 87.0), CATAMERI (AUC 0.98 vs 0.86; Δ 0.12; sensitivity 75.0 vs 69.4; specificity: 98.4 vs 78.9), GENFIEV (AUC 0.97 vs 0.89; Δ 0.08; sensitivity 89.5 vs 69.4; specificity 100.0 vs 88.3), PLIS follow-up (AUC 0.98 vs 0.76; Δ 0.22; sensitivity 94.9 vs 46.8; specificity 100.0 vs 92.3) and TULIP follow-up (AUC 0.98 vs 0.83; Δ 0.15; sensitivity 90.2 vs 90.2; specificity 100.0 vs 65.0) compared with FPG plus HbA CONCLUSIONS/

interpretationThese findings support the superior utility of the IDF-recommended 1 h PG vs FPG, 2 h PG, HbA

Indexed as

Blood GlucoseDiabetes Mellitus, Type 2FastingGlycated HemoglobinAdultAgedFemaleGlucose Tolerance TestHumansMaleMiddle AgedROC CurveBlood GlucoseGlycated Hemoglobinhemoglobin A1c protein, human1 h plasma glucose2 h plasma glucoseFasting plasma glucoseHbA1cIntermediate hyperglycaemiaMeta-analysisType 2 diabetes diagnosis

Identifiers

PMID41388091
PMCPMC12957105

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.