ArticleCommunications biology2025
Planar lightsheet optical tweezer pLOT for 2D trapping and imaging of freely-moving live cells.
Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
We report the realization of the first planar optical trap and imaging system using a sheet of light that allows interrogation of living specimens in a plane. An orthogonal widefield detection is employed to directly visualize the trapping of the target object (dielectric beads/cells) in a plane. The planar trap is realized on an inverted optical stage with illumination from the bottom. The system uses a combination of a cylindrical lens and a high NA objective lens to generate a tightly focused diffraction-limited sheet of light. For trapping objects in a selective XZ-plane, the sample (beads/cells suspended in a solution) is illuminated by a sheet of light (along the Z-axis with coverslip along XZ), whereas the detection is carried out perpendicular to the coverslip (along the Y-axis). Orthogonal detection allows direct visualization of the trapped object in the 2D plane illuminated by the lightsheet. The generated PSF has a dimension of 2073.84 μm
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