Evidence map›Paper›PMID 41388072›Full record

ArticleCommunications biology2025

Characterisation of an unusual nicotinic acetylcholine receptor subtype preferentially sensitive to biogenic amines.

Eleanor L Mitchell, Emily B Armstrong, Franco Viscarra, Isabel Bermudez, Philip C Biggin, James A Goodchild, Andrew K Jones

Abstract read
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Eleanor L Mitchell *School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, UK.ORCID http://orcid.org/0000-0001-7900-2292
Emily B Armstrong *Department of Biological and Medical Sciences, Faculty of Health and Life Sciences, Oxford Brookes University, Headington, Oxford, United Kingdom.ORCID http://orcid.org/0009-0009-5575-9704
Franco ViscarraDepartment of Biological and Medical Sciences, Faculty of Health and Life Sciences, Oxford Brookes University, Headington, Oxford, United Kingdom.ORCID http://orcid.org/0000-0001-7891-7546
Isabel BermudezDepartment of Biological and Medical Sciences, Faculty of Health and Life Sciences, Oxford Brookes University, Headington, Oxford, United Kingdom.
Philip C BigginStructural Bioinformatics and Computational Biochemistry, Department of Biochemistry, University of Oxford, Oxford, United Kingdom.ORCID http://orcid.org/0000-0001-5100-8836
James A GoodchildSyngenta, Jealott's Hill International Research Centre, Berkshire, United Kingdom.ORCID http://orcid.org/0000-0002-4590-9758
Andrew K JonesDepartment of Biological and Medical Sciences, Faculty of Health and Life Sciences, Oxford Brookes University, Headington, Oxford, United Kingdom. a.jones@brookes.ac.uk.ORCID http://orcid.org/0000-0002-7835-0890

Funding

RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) BB/M011224/1
6 · The paper itself

Abstract

Nicotinic acetylcholine receptors (nAChRs) are best known for mediating the fast actions of acetylcholine. However, the spectrum of other neurotransmitters possibly acting on these receptors is not well understood. Here, we report that the α5 nAChR subunit of the honey bee, Apis mellifera, when expressed in Xenopus laevis oocytes, has unusual pharmacological properties in that it has high sensitivity towards dopamine, tyramine and octopamine with EC

Indexed as

Biogenic AminesReceptors, NicotinicAcetylcholineAnimalsBeesMolecular Dynamics SimulationOocytesPhylogenyXenopus laevisAcetylcholineBiogenic AminesReceptors, Nicotinic

Identifiers

PMID41388072
PMCPMC12700902

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.