Evidence map›Paper›PMID 41388007›Full record

ArticleScientific reports2025

Porous tantalum cage loaded with CGF promotes interbody fusion in a rat XLIF model.

Han Wu, Weijian Wang, Shaorong Li, Jianshi Song, Sidong Yang, Qiang Yang, Liang Li, Ruixin Zhen, Haoyu Wu, Wei Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Han WuGraduate School, Hebei Medical University, Shijiazhuang, Hebei, China.
Weijian WangGraduate School, Hebei Medical University, Shijiazhuang, Hebei, China.
Shaorong LiGraduate School, Hebei Medical University, Shijiazhuang, Hebei, China.
Jianshi SongGraduate School, Hebei Medical University, Shijiazhuang, Hebei, China.
Sidong YangDepartment of Spine Surgery, The Third hospital of Hebei Medical University, 139 Ziqiang Street, Shijiazhuang, 050031, Hebei, China.
Qiang YangDepartment of Spine Surgery, Tianjin Hospital, Tianjin University, Tianjin, China.
Liang LiDepartment of Spine Surgery, The Third hospital of Hebei Medical University, 139 Ziqiang Street, Shijiazhuang, 050031, Hebei, China.
Ruixin ZhenHealth Management Centre, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Haoyu WuGraduate School, Hebei Medical University, Shijiazhuang, Hebei, China.
Wei ZhangDepartment of Spine Surgery, The Third hospital of Hebei Medical University, 139 Ziqiang Street, Shijiazhuang, 050031, Hebei, China. 37300332@hebmu.edu.cn.

Funding

S&T Program of Hebei 22377708D
6 · The paper itself

Abstract

This study addresses the clinical challenge of nonunion in spinal interbody fusion by developing a novel composite implant: a porous tantalum (PTa) cage loaded with concentrated growth factors (CGF). The CGF-PTa cage synergistically combines the mechanical strength and osteoconductivity of chemically vapor-deposited PTa with the sustained release of angiogenic (VEGF) and osteogenic (TGF-β and IGF-1) factors from CGF. Using a rat extreme lateral interbody fusion (XLIF) model, the research systematically evaluates the efficacy of this composite in promoting bone regeneration and spinal fusion. Results from radiography, micro-CT, biomechanical testing, histological staining, and immunohistochemistry consistently show that CGF-PTa significantly enhances bone ingrowth, fusion rate, and mechanical stability compared to PTa alone. The findings also reveal that CGF facilitates angiogenesis and osteogenesis by modulating the local healing microenvironment and promoting vascular-osteogenic coupling. Importantly, the CGF-PTa system demonstrated excellent biocompatibility and biodegradability in vivo, with no observed systemic toxicity. This work highlights the potential of combining bioactive factors with porous metallic scaffolds to overcome the limitations of inert implants in avascular environments, offering a promising strategy for functional optimization of interbody fusion devices and their future clinical application.

Indexed as

Intercellular Signaling Peptides and ProteinsSpinal FusionTantalumAnimalsBone RegenerationMaleOsteogenesisPorosityRatsRats, Sprague-DawleyTransforming Growth Factor betaVascular Endothelial Growth Factor AX-Ray MicrotomographyIntercellular Signaling Peptides and ProteinsTantalumTransforming Growth Factor betaVascular Endothelial Growth Factor AChemical vapor depositionConcentrated growth factorsInterbody fusionPorous tantalum cageRat modelXLIF

Identifiers

PMID41388007
PMCPMC12804753

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.