ArticleJournal of diabetes investigation2026
Risk factors for persistent decline in eGFR of Japanese patients with diabetes: Analysis using a large-scale diabetes registry J-DREAMS.
Article in Journal of diabetes investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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6 authors.
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Abstract
AIMS/
introductionThis study aimed to identify clinical predictors associated with sustained decline in estimated glomerular filtration rate (eGFR) among Japanese individuals diagnosed with diabetes mellitus. MATERIALS AND
methodsWe conducted a retrospective analysis using J-DREAMS (Japan Diabetes compREhensive database project based on an Advanced Electronic Medical record System), a large-scale registry integrated with electronic medical records. The study population included adults (≥18 years) with diabetes who had at least one documented visit at a referral institution between December 1, 2015, and March 31, 2021, with concurrent measurements of serum creatinine and hemoglobin.
resultsA total of 12,416 and 11,157 patients were eligible for assessment of eGFR change at 1 and 2 years, respectively. Multivariable logistic regression identified several consistent risk factors for ≥30% eGFR reduction at both time points: low serum albumin, elevated triglycerides, anemia as defined by JSDT, diabetic retinopathy, CKD Stage G4 or higher, albuminuria category A3, and chronic heart failure. Additional predictors at 1 year included age under 65 and elevated HbA1c, while smoking, hypertension, and diabetic neuropathy were significant only at 2 years.
conclusionBeyond retinopathy and advanced kidney disease, anemia, hypoalbuminemia, and heart failure independently contributed to persistent eGFR decline, supporting the clinical relevance of cardio-renal anemia syndrome in diabetic populations.
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