ArticleScientific reports2025
Preparation of silver-loaded metal-organic frameworks as a novel agent for arresting dental caries of primary teeth.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
This study assessed the remineralization efficacy of a novel agent that contains silver-loaded metal-organic frameworks with fluoride (Ag@MOF/F) on dentin surface of primary teeth. Ag@MOF/F was prepared and characterized by scanning electron microscopy (SEM). The dentin surfaces of 104 sound primary canine were demineralized for 4 days and randomly divided into four groups (n = 26/group): (1) 400 ppm Ag@MOF/F, (2) 1400 ppm Ag@MOF/F, (3) 38% silver diamine fluoride (SDF), and (4) 5% sodium fluoride (NaF). Topographic changes, depth of penetration, and crystal formation were evaluated by SEM, energy-dispersive spectroscopy (EDS), and X-ray diffraction (XRD), respectively. Vickers microhardness and spectrophotometry were used to assess surface hardness and discoloration of the samples. The 1400 ppm Ag@MOF/F group indicated greater depth of penetration and sharper hydroxyapatite peak than the SDF and NaF. The 1400 ppm Ag@MOF/F group had a significantly greater increase in surface and cross-sectional microhardness than the other groups (P < 0.001). The 400 ppm Ag@MOF/F and SDF groups showed similar recovery of microhardness (P = 0.913). SDF-treated specimens were significantly darker than the other groups (P < 0.05), whereas the Ag@MOF/F samples had minimal discoloration. Our results indicate that Ag@MOF/F can be an alternative for SDF in arresting dentin caries because of its enhanced remineralization property and minimal discoloration.
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