ArticleNature communications2025
Asymmetric synthesis of stereogenic-at-sulfur compounds via biocatalytic oxidation with Unspecific Peroxygenases.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The trial behind it
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Who cites it
5 citing papers in PubMed.
- Structure, characterisation and application of an unspecific peroxygenase fromRSC chemical biology · 2026Article
- Catalytic Enantioselective Construction of Carbon-Sulfur Bonds: Recent Advances and Future Perspectives.Molecules (Basel, Switzerland) · 2026Review
- Empowering Precision C-H Functionalization: Advances in Peroxygenase Engineering.Angewandte Chemie (International ed. in English) · 2026Review
- Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis.Angewandte Chemie (International ed. in English) · 2026Review
- High-Fidelity Transfer of Chiral Sulfonimidoyl Radicals.Journal of the American Chemical Society · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Stereogenic-at-sulfur compounds are vitally important biologically active small molecules, with many drugs featuring chiral sulfur atoms. Methods for the asymmetric synthesis of sulfoxide centres are well established, but methods that produce enantiomerically enriched sulfoximines and sulfinimines are far less well developed, with no known biocatalytic methods based on oxygenation. In this study, we demonstrate that Unspecific Peroxygenases (UPOs) catalyse the biocatalytic oxygenation of sulfilimines and sulfenimines to form enantiomerically enriched sulfoximines and sulfinimines respectively, on preparative scale. In the sulfilimine series, sulfoximines are generated in up to 98% ee via a kinetic resolution approach. In the sulfenimine series, the selective, synthesis of both (R)- and (S)-sulfinimine products (both up to 99% ee) can be achieved, with different UPOs affording products with opposite enantioselectivity. Both series represent additional applications of UPO technology to an ever-growing list of selective, practical and industrially relevant biotransformations.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.