Evidence map›Paper›PMID 41387950›Full record

ArticleScientific reports2025

Leveraging TRPV1 for intracellular delivery of membrane impermeant compounds in the brain.

José C Zepeda, Loren D Peeters, Pragnya S Adapa, Beimnet B Kassaye, Brad A Grueter

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

José C ZepedaDepartment of Pharmacology, Vanderbilt University, Nashville, TN, 37232, USA.
Loren D PeetersDepartment of Anesthesiology, Vanderbilt University Medical Center, 2213 Garland Avenue P435H MRB IV, Nashville, TN, 37232, USA.
Pragnya S AdapaCollege of Arts & Sciences, Vanderbilt University, Nashville, TN, 37232, USA.
Beimnet B KassayeVanderbilt Brain Institute, Vanderbilt University, Nashville, TN, 37232, USA.
Brad A GrueterDepartment of Pharmacology, Vanderbilt University, Nashville, TN, 37232, USA. brad.grueter@vumc.org.

Funding

Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jeffrey L Neul · 2020 to 2026
$10.3M
Parvalbumin interneurons regulate nucleus accumbens synapses and behaviorR01DA040630 · NIDA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GRUETER, BRAD ALAN · 2016 to 2025
$4.5M
National Science Foundation NSF GRFP 1937963NICHD NIH HHS P50 HD103537NIDA NIH HHS R01 DA040630
6 · The paper itself

Abstract

Large-pore ion channels present a window of opportunity for cell-specific intracellular drug delivery. Here, we demonstrate that the capsaicin receptor, TRPV1, can be used for delivery of the membrane impermeant lidocaine derivative QX-314 into neurons in the brain in vivo by using drug-induced hyperlocomotion as a behavioral readout and we validated our findings with ex vivo electrophysiological recordings. Our studies present evidence that this strategy can be used to deliver membrane impermeant compounds in the brain.

Indexed as

BrainDrug Delivery SystemsLidocaineTRPV Cation ChannelsAnimalsMaleMiceNeuronsLidocaineQX-314TRPV1 protein, mouseTRPV Cation Channels

Identifiers

PMID41387950
PMCPMC12804837

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.