Evidence map›Paper›PMID 41387943›Full record

Observational studyScientific reports2025

Subchondral bone strength of the metacarpal head and its related factors in patients with rheumatoid arthritis.

Rika Kakutani, Hiroto Yoshida, Naoki Kondo, Mariko Noguchi-Sasaki, Hajime Ishikawa

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rika KakutaniDivision of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-Ku, Niigata, 951-8510, Japan.
Hiroto YoshidaProduct Research Department, Chugai Pharmaceutical Co., Ltd, 216 Totsuka-cho, Totsuka-Ku, Yokohama, 244-8602, Kanagawa, Japan.
Naoki KondoDivision of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-Ku, Niigata, 951-8510, Japan. naokikondo1214@gmail.com.
Mariko Noguchi-SasakiProduct Research Department, Chugai Pharmaceutical Co., Ltd, 216 Totsuka-cho, Totsuka-Ku, Yokohama, 244-8602, Kanagawa, Japan.
Hajime IshikawaDepartment of Rheumatology, Niigata Rheumatic Center, 1-2-8 Honcho, Shibata, 957-8588, Niigata, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Factors affecting bone strength have not been elucidated in patients with rheumatoid arthritis (RA) undergoing silicone implant arthroplasty. In this observational study, we aimed to investigate factors affecting bone strength. We measured toughness in terms of bone strength, bone mineral density, and bone quality of 105 resected metacarpal heads (I:32, II:36, III:33, IV:2, V:2) obtained during silicone implant arthroplasty at the metacarpophalangeal (MP) joint in patients with RA. Bone strength was associated with all parameters in micro-computed tomography (µCT) and all parameters in bone histomorphometry, other than osteoid volume and osteoid surface. Clinical factors associated with bone strength included prednisolone (PSL) dose at the time of surgery, % young adult mean, T-score and the Rooney score. Bone volume fraction by µCT only influenced bone strength per multiple linear regression analysis. Compared to joints with higher bone strength, those with lower bone strength had a higher magnitude of implant subsidence, which assumed to the risk of reduced mobility and implant fracture after the operation. Suppressing the degradation of subchondral bone structures by continuously ameliorating disease activity without the use of PSL appeared to be crucial to maintain the radiological appearance of silicone implant arthroplasty at the MP joint.

Indexed as

Arthritis, RheumatoidMetacarpal BonesMetacarpophalangeal JointAdultAgedBone DensityFemaleHumansMaleMiddle AgedX-Ray MicrotomographyBone histomorphometryBone mineral densityBone strengthMicro-computed tomographyRheumatoid arthritis

Identifiers

PMID41387943
PMCPMC12804749

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.