Evidence map›Paper›PMID 41387816›Full record

ReviewBMC neurology2025

Paraneoplastic cochleovestibulopathy associated with breast cancer: a case report of two patients and literature review.

Liqin Yang, Xueqing Liu, Wenxia Li, Songming Tang, Yanan Hu, Ting Zhang, Xun Li, Wei Yue, Shujuan Tian

Abstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in BMC neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Liqin YangDepartment of Neurology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050030, China.
Xueqing LiuDepartment of Neurology, Clinical College of Neurology, Neurosurgery, and Neurorehabilitation, Tianjin Medical University, Tianjin Huanhu Hospital, No.6 Jizhao Road, Shuanggang Town, Jinnan District, Tianjin, 300350, China.
Wenxia LiDepartment of Neurology, Clinical College of Neurology, Neurosurgery, and Neurorehabilitation, Tianjin Medical University, Tianjin Huanhu Hospital, No.6 Jizhao Road, Shuanggang Town, Jinnan District, Tianjin, 300350, China.
Songming TangSchool of Mathematical Sciences and LPMC, Nankai University, Tianjin, China.
Yanan HuTianjin University of Traditional Chinese Medicine, Tianjin Huanhu Hospital, Tianjin, China.
Ting ZhangDepartment of Neurology, Clinical College of Neurology, Neurosurgery, and Neurorehabilitation, Tianjin Medical University, Tianjin Huanhu Hospital, No.6 Jizhao Road, Shuanggang Town, Jinnan District, Tianjin, 300350, China.
Xun LiDepartment of Neurology, Clinical College of Neurology, Neurosurgery, and Neurorehabilitation, Tianjin Medical University, Tianjin Huanhu Hospital, No.6 Jizhao Road, Shuanggang Town, Jinnan District, Tianjin, 300350, China.
Wei YueDepartment of Neurology, Clinical College of Neurology, Neurosurgery, and Neurorehabilitation, Tianjin Medical University, Tianjin Huanhu Hospital, No.6 Jizhao Road, Shuanggang Town, Jinnan District, Tianjin, 300350, China. hhyuewei2008@163.com.
Shujuan TianDepartment of Neurology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050030, China. 57203005@hebmu.edu.cn.

Funding

the National Key Research and Development Program of China 2022YFC3600500, 2022YFC3600503the Nature Science Foundation of Hebei Province H2020206632This study was supported by Tianjin Key Medical Discipline (Specialty) Construction Project No. TJYXZDXK-052BTianjin Health Commission Science and Technology Projects TJWJ2021QN061 and ZC20134
6 · The paper itself

Abstract

backgroundParaneoplastic cochleovestibulopathy (PCVP) is a rare, atypical neurological paraneoplastic syndrome of the nervous system that is often misdiagnosed and mistreated. CASE PRESENTATION: We report two cases of middle-aged women who presented with bilateral sensorineural hearing loss (SNHL) as the initial symptom. Pure-tone audiometry (PTA) demonstrated bilateral hearing impairment, while brainstem auditory evoked potentials (BAEP) and cochlear electrograms were within normal limits. Otoacoustic emissions indicated bilateral cochlear dysfunction. Cranial imaging excluded intracranial organic and vascular lesions. After corticosteroid therapy proved ineffective, positron emission tomography/computed tomography (PET/CT) combined with histopathological examination confirmed the presence of breast cancer, leading to a diagnosis of PCVP. Despite receiving endocrine therapy (Case 1) or surgical excision (Case 2), neither patient exhibited significant improvement in PTA during one year of follow-up.

conclusionPCVP should be considered in middle-aged patients who present with progressive bilateral hearing loss, often accompanied by vestibular dysfunction and clinical signs of cerebellar or brainstem involvement. Regular monitoring with PET/CT is recommended, and female patients in particular should undergo screening for breast cancer.

Indexed as

Breast NeoplasmsHearing Loss, SensorineuralParaneoplastic SyndromesEvoked Potentials, Auditory, Brain StemFemaleHumansMiddle AgedBreast cancerCase reportHearing lossNeurological paraneoplastic syndrome

Identifiers

PMID41387816
PMCPMC12699930

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.