ArticleScientific reports2025
Immunity to six vaccine pathogens in HIV positive and HIV negative children in Equatorial Guinea.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vaccination prevents millions of childhood deaths annually, yet 23 million infants still miss essential vaccines, mostly in Sub-Saharan Africa. Low coverage is particularly concerting in countries with high paediatric HIV prevalence. In Equatorial Guinea, where 6% of children live with HIV and vaccination coverage remains limited, information on vaccine-induced immunity is scarce. We conducted a cohort study to evaluate immunity against six vaccine-preventable diseases in HIV-exposed children from Bata. Plasma samples from 69 children (55 HIV+/14 exposed uninfected) collected between 2019 and 2021 were analysed by a chemiluminescent immunoassay. Despite antiretroviral therapy, only 18.5% of HIV + children achieved viral suppression. Reported vaccination coverage for DTP and measles was lower than WHO-UNICEF estimates. IgG antibody levels was 68.1% for diphtheria, 13% for tetanus, 5.8% for pertussis, and 49.3% for measles. Although mumps and rubella vaccines are not included in the national schedule, antibody prevalence was 79.7% and 59.4%, respectively, suggesting natural exposure. Vaccination records were incomplete for half of the children. HIV-exposed children in EG show insufficient antibody levels against major vaccine-preventable pathogens. Strengthening immunization services, improving vaccine record systems, and tailoring strategies for HIV-exposed children are critical priorities.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.