Evidence map›Paper›PMID 41387629›Full record

ReviewCommunications medicine2025

Clinical recognition of frontotemporal dementia with right temporal predominance: a consensus statement from the International Working Group.

Hulya Ulugut, Kyan Younes, Maxime Montembeault, Maxime Bertoux, Muireann Irish, Fiona Kumfor, Giorgio G Fumagalli, Bedia Samanci, Ignacio Illán-Gala, Jennifer C Thompson and 32 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Communications medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

42 authors.

Hulya UlugutAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands. hulya.ulugut@ucsf.edu.ORCID http://orcid.org/0000-0002-5016-2505
Kyan YounesMemory and Aging Center, Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Maxime MontembeaultMemory and Aging Center, Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-9369-0498
Maxime BertouxLille Neuroscience & Cognition U1172, Inserm, CHU Lille, LiCEND & Labex DistALZ, University Lille, Lille, France.ORCID http://orcid.org/0000-0002-5283-503X
Muireann IrishBrain and Mind Centre, University of Sydney, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0002-4950-8169
Fiona KumforBrain and Mind Centre, University of Sydney, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0002-3208-075X
Giorgio G FumagalliDepartment of Neurology, University of Milan, Milan, Italy.ORCID http://orcid.org/0000-0003-0687-7199
Bedia SamanciDepartment of Neurology, Istanbul University, Istanbul, Turkey.ORCID http://orcid.org/0000-0003-0667-2329
Ignacio Illán-GalaSant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; Centro de Investigación en Red-Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
Jennifer C ThompsonCerebral Function Unit, Manchester Centre for Clinical Neurosciences, Northern Care Alliance NHS Foundation Trust, Salford, UK; Division of Neuroscience and Experimental Psychology, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Alexander F SantilloClinical Memory Research Unit, Department of Clinical Sciences, Faculty of Medicine, Lund University, Lund, Sweden.ORCID http://orcid.org/0000-0001-9717-0820
Elisabet EnglundDivision of Pathology, Department of Clinical Sciences, Lund University, Lund, Sweden.ORCID http://orcid.org/0000-0002-2708-2443
Maria Landqvist WaldöDivision of Clinical Sciences Helsingborg, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Lina RiedlSchool of Medicine, Department of Psychiatry and Psychotherapy, Technical University of Munich, Munich, Germany.
Jan Van den StockNeuropsychiatry, Department of Neurosciences, Leuven Brain Institute, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0001-5756-3195
Mathieu VandenbulckeNeuropsychiatry, Department of Neurosciences, Leuven Brain Institute, KU Leuven, Leuven, Belgium.
Rik VandenbergheNeurology Service, University Hospitals Leuven, Leuven, Belgium; and Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0001-6237-2502
Robert LaforceClinique Interdisciplinaire de Mémoire (CIME), Département des Sciences Neurologiques, Laval University, Quebec City, Canada.ORCID http://orcid.org/0000-0002-2031-490X
Simon DucharmeDepartment of Psychiatry, Douglas Mental Health University Institute, McGill University Health Centre, McGill University, Montreal, QC, Canada.
Peter S PressmanDepartment of Neurology, Anschutz Medical Campus, Behavioral Neurology Section, University of Colorado, Boulder, CO, USA.
Paulo CaramelliBehavioral and Cognitive Neurology Research Group, Department of Internal Medicine, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.ORCID http://orcid.org/0000-0002-4786-6990
Leonardo Cruz de SouzaBehavioral and Cognitive Neurology Research Group, Department of Internal Medicine, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Leonel T TakadaCognitive and Behavioral Unit, Hospital das Clinicas, Department of Neurology, University of São Paulo Medical School, São Paulo, Brazil.
Hakan GurvitDepartment of Neurology, Istanbul University, Istanbul, Turkey.
Janine Diehl-SchmidSchool of Medicine, Department of Psychiatry and Psychotherapy, Technical University of Munich, Munich, Germany.
Daniela GalimbertiDepartment of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.ORCID http://orcid.org/0000-0002-9284-5953
Florence PasquierLille Neuroscience & Cognition U1172, Inserm, CHU Lille, LiCEND & Labex DistALZ, University Lille, Lille, France.ORCID http://orcid.org/0000-0001-9880-9788
Sandra WeintraubMesulam Center for Cognitive Neurology and Alzheimer's Disease Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-2605-5205
Bruce L MillerMemory and Aging Center, Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Virginia E SturmMemory and Aging Center, Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-1717-298X
Jennifer L WhitwellDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Bradley BoeveDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-4153-8187
Jonathan D RohrerDementia Research Centre, UCL Queen Square Institute of Neurology, London, UK.
Olivier PiguetBrain and Mind Centre, University of Sydney, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0002-6696-1440
Maria Luisa Gorno-TempiniMemory and Aging Center, Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Keith A JosephsDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0003-2930-8634
Julie SnowdenCerebral Function Unit, Manchester Centre for Clinical Neurosciences, Northern Care Alliance NHS Foundation Trust, Salford, UK; Division of Neuroscience and Experimental Psychology, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.ORCID http://orcid.org/0000-0002-3976-4310
James B RoweDepartment of Clinical Neurosciences and Cambridge University Hospitals NHS Trust and Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-7216-8679
Jason D WarrenDementia Research Centre, UCL Queen Square Institute of Neurology, London, UK.
Katherine P RankinMemory and Aging Center, Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-3611-0848
Yolande A L PijnenburgAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
International rtvFTD working group

Funding

TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
Emotion network dysfunction and decline in early frontotemporal dementiaR01AG052496 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Virginia Emily Sturm · 2017 to 2026
$6.9M
Understanding the role of TDP-43 in Alzheimers disease and FTLDR01AG037491 · NIA · MAYO CLINIC ROCHESTER · PI JOSEPHS, KEITH A · 2010 to 2024
$6.5M
Attention and Semantic Evaluation as Predictors of Empathy in Healthy Aging and Frontotemporal DementiaRF1AG029577 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RANKIN, KATHERINE P · 2019 to 2019
$4.0M
Measuring Altered Social Behavior in Neurodegenerative DiseaseR01AG029577 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RANKIN, KATHERINE P · 2008 to 2018
$3.6M
PIB PET Scanning in Speech and Language Based DementiasR01DC010367 · NIDCD · MAYO CLINIC ROCHESTER · PI JOSEPHS, KEITH A · 2010 to 2014
$1.7M
Assessment of hyperphosphorylated tau PET binding in primary progressive aphasiaR21NS094684 · NINDS · MAYO CLINIC ROCHESTER · PI JOSEPHS, KEITH A · 2016 to 2017
$417k
Neuroimaging and genetics of the glymphatic system in Alzheimer's diseaseK23AG090733 · NIA · STANFORD UNIVERSITY · PI Kyan Younes · 2025 to 2026
$332k
Alzheimer's Association AACSF-22-849085NIA NIH HHS K23 AG090733NIA NIH HHS P01 AG019724NIA NIH HHS R01 AG029577NIA NIH HHS R01 AG037491NIA NIH HHS R01 AG052496NIA NIH HHS RF1 AG029577NIDCD NIH HHS R01 DC010367NINDS NIH HHS R21 NS094684Wellcome Trust
6 · The paper itself

Abstract

Accurate diagnosis of frontotemporal dementia (FTD) with right anterior temporal lobe (RATL) predominance remains challenging due to lack of clinical characterization, and standardized terminology. The recent research of the International Working Group (IWG) identified common symptoms but also unveiled broad terminologies lacking precision and operationalization, with risk of misdiagnoses, inappropriate referrals and poor clinical management. Based on the published evidence (91267 articles screened) and expert opinion (105 FTD specialists across 52 centers) by using the nominal group technique, the IWG delineates three primary domains of impairment causing behavioral, memory and language problems: (i) multimodal knowledge of non-verbal information including people, living beings, landmarks, flavors/odors, sounds, bodily sensations, emotions and social cues; (ii) socioemotional behavior encompassing emotion expression, social response and motivation; and (iii) prioritization for focus on specific interests, hedonic valuation and personal preferences. This study establishes a consensus on clinical profile, phenotypic nomenclature, and future directions to enhance diagnostic precision and therapeutic interventions.

Identifiers

PMID41387629
PMCPMC12700944

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.