Evidence map›Paper›PMID 41387626›Full record

ArticleNature genetics2026

Telomere-to-telomere genome assembly of a male pig provides insight into population structure and selection for body stature.

Ya-Biao Luo, Ning Huang, Cheng-Wan Zha, Li-Xian Yang, Peng-Xiang Xue, Qiao Xu, Xiao-Yang Yang, Long-Miao Zhang, Yu-Bei Wang, Zhe Chao and 4 more

Abstract read
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In one paragraph

Article in Nature genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ya-Biao Luo *State Key Laboratory of Animal Biotech Breeding, National Engineering Laboratory for Animal Breeding, MOA Key Laboratory of Animal Genetics and Breeding, College of Animal Science and Technology, Frontiers Science Center for Molecular Design Breeding, Beijing Key Laboratory for Animal Genetic Improvement, China Agricultural University, Beijing, China.
Ning Huang *State Key Laboratory of Animal Biotech Breeding, National Engineering Laboratory for Animal Breeding, MOA Key Laboratory of Animal Genetics and Breeding, College of Animal Science and Technology, Frontiers Science Center for Molecular Design Breeding, Beijing Key Laboratory for Animal Genetic Improvement, China Agricultural University, Beijing, China.
Cheng-Wan Zha *State Key Laboratory of Animal Biotech Breeding, National Engineering Laboratory for Animal Breeding, MOA Key Laboratory of Animal Genetics and Breeding, College of Animal Science and Technology, Frontiers Science Center for Molecular Design Breeding, Beijing Key Laboratory for Animal Genetic Improvement, China Agricultural University, Beijing, China.
Li-Xian YangState Key Laboratory of Animal Biotech Breeding, National Engineering Laboratory for Animal Breeding, MOA Key Laboratory of Animal Genetics and Breeding, College of Animal Science and Technology, Frontiers Science Center for Molecular Design Breeding, Beijing Key Laboratory for Animal Genetic Improvement, China Agricultural University, Beijing, China.
Peng-Xiang XueState Key Laboratory of Animal Biotech Breeding, National Engineering Laboratory for Animal Breeding, MOA Key Laboratory of Animal Genetics and Breeding, College of Animal Science and Technology, Frontiers Science Center for Molecular Design Breeding, Beijing Key Laboratory for Animal Genetic Improvement, China Agricultural University, Beijing, China.
Qiao XuState Key Laboratory of Animal Biotech Breeding, National Engineering Laboratory for Animal Breeding, MOA Key Laboratory of Animal Genetics and Breeding, College of Animal Science and Technology, Frontiers Science Center for Molecular Design Breeding, Beijing Key Laboratory for Animal Genetic Improvement, China Agricultural University, Beijing, China.
Xiao-Yang YangState Key Laboratory of Animal Biotech Breeding, National Engineering Laboratory for Animal Breeding, MOA Key Laboratory of Animal Genetics and Breeding, College of Animal Science and Technology, Frontiers Science Center for Molecular Design Breeding, Beijing Key Laboratory for Animal Genetic Improvement, China Agricultural University, Beijing, China.
Long-Miao ZhangState Key Laboratory of Animal Biotech Breeding, National Engineering Laboratory for Animal Breeding, MOA Key Laboratory of Animal Genetics and Breeding, College of Animal Science and Technology, Frontiers Science Center for Molecular Design Breeding, Beijing Key Laboratory for Animal Genetic Improvement, China Agricultural University, Beijing, China.
Yu-Bei WangState Key Laboratory of Animal Biotech Breeding, National Engineering Laboratory for Animal Breeding, MOA Key Laboratory of Animal Genetics and Breeding, College of Animal Science and Technology, Frontiers Science Center for Molecular Design Breeding, Beijing Key Laboratory for Animal Genetic Improvement, China Agricultural University, Beijing, China.
Zhe ChaoInstitute of Animal Science and Veterinary Medicine, Hainan Academy of Agricultural Science, Haikou, China.
Rui-Ping SunInstitute of Animal Science and Veterinary Medicine, Hainan Academy of Agricultural Science, Haikou, China.
Feng WangInstitute of Animal Science and Veterinary Medicine, Hainan Academy of Agricultural Science, Haikou, China.
Shan-Gang JiaCollege of Grassland Science and Technology, China Agricultural University, Beijing, China. shangang.jia@cau.edu.cn.ORCID 0000-0002-3306-7637
Mei-Ying FangState Key Laboratory of Animal Biotech Breeding, National Engineering Laboratory for Animal Breeding, MOA Key Laboratory of Animal Genetics and Breeding, College of Animal Science and Technology, Frontiers Science Center for Molecular Design Breeding, Beijing Key Laboratory for Animal Genetic Improvement, China Agricultural University, Beijing, China. meiying@cau.edu.cn.ORCID 0000-0001-8732-745X

Funding

National Natural Science Foundation of China (National Science Foundation of China) U22A20508<
6 · The paper itself

Abstract

A complete telomere-to-telomere (T2T) genome is essential for advancing pig genomic research. Here we assembled a pig T2T gap-free genome T2T-pig1.0 (2.63 Gb) for a boar in Wuzhishan, China, covering all 20 chromosomes. T2T-pig1.0 with an accuracy of >99.999% uncovers 194.42 Mb of previously unresolved regions (PURs), and 1,189 new genes are added to the current reference genome Sscrofa11.1. We annotated 111 protein-coding genes with 11 male-specific conserved orthologous genes on chromosome Y (43.25 Mb). Pig-specific centromeric satellite repeat units are revealed. Centromeric regions of all telocentric chromosomes harbor a unique structure, 'telomere-SAT1B-(mSAT)ₙ-SAT3-q_arm', and a few young long terminal repeats. With the addition of 339,092 single-nucleotide polymorphisms in PURs, the population structure is updated with cross-continental introgression, and a selective sweep analysis reveals 280 new regions and 133 new genes potentially associated with body stature. GALNT13, with strong selection signals, has a role in inhibiting porcine chondrocyte proliferation while promoting chondrocyte differentiation.

Indexed as

Body HeightGenomeSelection, GeneticSus scrofaTelomereAnimalsCentromereGenetics, PopulationMalePolymorphism, Single NucleotideSwine

Identifiers

PMID41387626

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.