ArticleNature microbiology2026
Interferon-stimulated gene GALNT2 restricts respiratory virus infections.
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Article in Nature microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2citing papers in PubMed
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Who cites it
2 citing papers in PubMed.
- Repeated mutation of a GT92 glycosyltransferase gene confers antiviral resistance in two Caenorhabditis species.Molecular biology and evolution · 2026Article
- Beyond Viral Restriction: The Metabolic Dimensions of Interferon-Stimulated Genes in Antiviral Immunity.Viruses · 2026Review
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Authors and funding
46 authors.
Wei Ran *The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China.
Jinghong Yang *The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China.
Shi Yu *Guangzhou National Laboratory, Guangzhou International Bio Island, Guangzhou, China.ORCID http://orcid.org/0000-0003-0651-4769
Qingtao Hu *The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China.ORCID http://orcid.org/0000-0002-8291-7116
Yuqi He *School of Pharmaceutical Sciences, National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation, Sun Yat-sen University, Guangzhou, China.
Shengjun WangSchool of Pharmaceutical Sciences, National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation, Sun Yat-sen University, Guangzhou, China.ORCID http://orcid.org/0000-0002-8044-7018
Cheng WeiThe First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China.
Jing SunThe First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China.
Airu ZhuThe First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China.
Fang LiThe First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China.
Lu ZhangGuangzhou Customs District Technology Center, Guangzhou, China.
Pengfei LiDepartment of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA.
Huina HuGuangzhou National Laboratory, Guangzhou International Bio Island, Guangzhou, China.
Ruangang PanDepartment of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA.ORCID http://orcid.org/0000-0002-9336-9717
Yanying YuSchool of Medicine, Tsinghua University, Beijing, China.
Yanqiu YuanSchool of Pharmaceutical Sciences, National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation, Sun Yat-sen University, Guangzhou, China.
Lingyu SunSchool of Pharmaceutical Sciences, National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation, Sun Yat-sen University, Guangzhou, China.
Yanqun WangThe First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China.
Zhaoyong ZhangThe First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China.
Zhao ChenThe First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China.
Donglan LiuThe First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China.
Qihong YanThe First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China.ORCID http://orcid.org/0000-0003-1645-8764
Dong WangThe First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China.
Kuai YuThe First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China.
Yiliang WangThe First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China.
Jianfen ZhuoThe First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China.
Zhen ZhuangThe First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China.
Hua TaoGuangzhou National Laboratory, Guangzhou International Bio Island, Guangzhou, China.
Qiuhui ZengThe First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China.
Kaixin ZhouGuangzhou National Laboratory, Guangzhou International Bio Island, Guangzhou, China.
Fenghua ChenThe First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China.
Wenxuan TangThe First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China.
Yuzheng ZhouNational Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, the Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, China.
Rong BaiGuangzhou National Laboratory, Guangzhou International Bio Island, Guangzhou, China.
Yonghao XuDepartment of Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Na LiIntegrated Chinese and Western medicine hospital affiliated with Southern Medical University, Guangzhou, China.
Jun DaiGuangzhou Customs District Technology Center, Guangzhou, China.
Hongyu ZhaoThe First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China.
Jung-Eun ParkCollege of Veterinary Medicine, Chungnam National University, Daejeon, Republic of Korea.
Tao WangGuangDong GemPharmatech Co., Ltd., Foshan, China.
Qiang DingSchool of Medicine, Tsinghua University, Beijing, China. qding@tsinghua.edu.cn.ORCID http://orcid.org/0000-0002-6226-869X
Stanley PerlmanDepartment of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA. stanley-perlman@uiowa.edu.ORCID http://orcid.org/0000-0003-4213-2354
Jingxian ZhaoThe First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China. zhaojingxian@gird.cn.ORCID http://orcid.org/0000-0002-2615-3182
Yang MaoSchool of Pharmaceutical Sciences, National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation, Sun Yat-sen University, Guangzhou, China. maoyang3@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0002-9674-1158
Shaobo WangThe First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China. wang_shaobo@gzlab.ac.cn.ORCID http://orcid.org/0000-0003-0481-707X
Jincun ZhaoThe First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China. zhaojincun@gird.cn.ORCID http://orcid.org/0000-0003-2515-5589
Funding
Role of eicosanoids in pathogenic human CoV infectionsR01AI129269 · NIAID · UNIVERSITY OF IOWA · PI Stanley Perlman · 2016 to 2026
$4.7MNational Natural Science Foundation of China (National Science Foundation of China) 2022YFC2604100National Natural Science Foundation of China (National Science Foundation of China) 81971500National Natural Science Foundation of China (National Science Foundation of China) 82025001National Natural Science Foundation of China (National Science Foundation of China) 82402593National Natural Science Foundation of China (National Science Foundation of China) 82402594NIAID NIH HHS R01 AI129269
Abstract
The innate immune response involves interferons (IFNs), antiviral cytokines that upregulate numerous IFN-stimulated genes, many of which have uncharacterized functions and mechanisms. Here we performed transcriptomic profiling of lung tissues from wild-type and IFNAR
Indexed as
COVID-19InterferonsN-AcetylgalactosaminyltransferasesSARS-CoV-2AnimalsFemaleGlycosylationHumansImmunity, InnateInfluenza A virusLungMaleMiceMice, Inbred C57BLMice, KnockoutPolypeptide N-acetylgalactosaminyltransferaseInterferonsN-AcetylgalactosaminyltransferasesPolypeptide N-acetylgalactosaminyltransferaseSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.