ArticleScientific reports2025
Differential expression of miR-23a-3p/-210-3p and /-18b-5p in sudden sensorineural hearing loss patients: A North American cohort study.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Sudden sensorineural hearing loss (SSNHL) is an acquired idiopathic hearing loss in which recent studies have suggested that microRNAs (miRNAs) have a pathogenetic role. We assessed six specific miRNAs linked to SSNHL in serum samples drawn from 11 SSNHL patients and 11 age and sex matched controls. Quantitative real-time PCR Cycle threshold (Ct) values were normalized to an internal control to determine relative miRNA levels. Inter-group mean age, sex, mean or median normalized Ct values were compared using Independent Sample t, Chi-squared or Mann-Whitney U tests. The relative expression (ΔΔCt) of miR-210-3p, miR-23a-2p, miR18b-5p -2.75, -3.33, and - 1.29, corresponded to statistically different ΔCt values (Students T-test, p = 0.006; Mann-Whitney U, p = 0.001 and 0.02) and fold changes of 6.73, 10.87, and 2.45, respectively, in SSNHL patients compared with controls. No significant difference in the expression levels of miR-15a-5p, miR-143-3p, or miR-183-5p was found. This study supports consistent dysregulation of miR-210-3p/-23a-3p and - 18b-5p across different populations of SSNHL patients, suggesting that they play a key role in the pathogenesis of SSNHL.
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